电离辐射损伤的作用机制与药物策略
Ionizing radiation damage:mechanisms of action and drug strategies
于清华 1李振 2赵廷坤 3汤紫霞 2吕美 2王利涛4
作者信息
- 1. 山东第二医科大学药学院,山东潍坊 261053;济宁医学院药学院,山东日照 276826
- 2. 济宁医学院药学院,山东日照 276826;山东第一医科大学药学院,济南 250117
- 3. 山东第二医科大学药学院,山东潍坊 261053
- 4. 山东第二医科大学药学院,山东潍坊 261053;济宁医学院药学院,山东日照 276826;山东第一医科大学药学院,济南 250117
- 折叠
摘要
随着放射治疗在癌症等疾病治疗中的广泛应用和全球核安全环境的日益严峻,辐射损伤防治药物的研发成为研究的热点.电离辐射以其高能量特性,不仅能够通过靶向效应直接损害细胞DNA,还能通过非靶向效应间接影响细胞环境,导致细胞功能障碍甚至死亡.该文分析了电离辐射的损伤机制,探讨了抗氧化剂、细胞凋亡抑制剂、细胞因子和天然辐射防护剂4类抗辐射药物的作用原理及临床应用,可为治疗和预防电离辐射损伤提供参考.
Abstract
With wide applications of radiation therapy in the treatment of cancer and other diseases and amid the in-creasing concerns about global nuclear safety,the research and development of drugs against radiation damage has become a hot spot.Thanks to its high energy properties,ionizing radiation can not only directly damage cell DNA through targeted effects,but also indirectly affect the cell environment through non-targeted effects,leading to cell dysfunction and even death.In this paper,the mechanism of ionizing radiation damage was analyzed,and the mechanisms of action and clinical applications of four types of anti-radiation drugs,namely,antioxidant,apoptosis inhibitor,cytokine and natural radiation protection agent were discussed.These drugs have huge implications for alleviating the targeted and non-targeted effects caused by ionizing radiation.
关键词
电离辐射/辐射损伤/作用机制/药物策略/辐射防护Key words
ionizing radiation/radiation damage/mechanism of action/pharmacological strategies/radiation protec-tion引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据