Research progress in and applications of influenza virus pseudoviruses
Since emergence,the influenza virus has triggered numerous global pandemics and claimed more than ten million lives.This virus poses not only a severe threat to human life and health,but significant challenges to global economy and public health.The research on highly pathogenic influenza virus strains(such as H5 and H7)necessitates the use of biosafety level 3 laboratories,which significantly escalates the experimental risks and costs.The pseudovirus technology,as a relatively safe and effective research technique,has been applied in the studies of various high-risk viruses.Thanks to constant research and refinement,the pseudovirus technology for the influenza virus currently boasts such advantages as user-friendliness and good safety,and has been extensively used antibody neutralization and screening of antiviral drugs.This article reviews the research progress in the pseudovirus technology for the influenza virus.
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