骨骼干细胞在军事再生医学中的应用价值研究进展
Research progress in applicability of skeletal stem cells in military regenerative medicine
虞富豪 1丁丽 2朱恒3
作者信息
- 1. 军事科学院军事医学研究院,北京 100850;空军军医大学研究生院,西安 710032;空军军医大学空军特色医学中心血液科,北京 100142
- 2. 空军军医大学研究生院,西安 710032;空军军医大学空军特色医学中心血液科,北京 100142
- 3. 军事科学院军事医学研究院,北京 100850
- 折叠
摘要
军事训练和军事作业常导致多种形式的骨骼损伤,包括疲劳性骨折、急性骨折、骨软骨缺损、放射性骨损伤等.骨骼干细胞是近年来发现的人和高等动物骨骼组织内源性干细胞,具备分化为骨、软骨和骨髓基质的能力,是骨发育、骨稳态维持和骨再生修复的重要种子细胞之一.骨骼干细胞具有高度群体异质性和时空分布特异性,不同部位骨骼干细胞的细胞表型和修复能力不尽相同.因此,骨骼干细胞在不同军事损伤中的响应规律及机制有所差别.该文从骨骼干细胞来源、骨修复作用机制及其在军事再生医学中的潜在应用价值等方面进行综述.
Abstract
Military training and operations usually lead to such skeletal injuries as fatigue fractures,acute bone fractures,osteochondral defects,and radiation-induced bone injury.Skeletal stem cells(SSCs)are newly-identified innate tissue specific stem cells in skeletons which are capable of differentiating into bone,cartilage and bone marrow stromal tissues,and are one of the seed cells critical to the development,homeostasis,and regeneration of skeletons.SSCs are highly heterogenous in cellular subpopulations and spatiotemporal distributions,which is why their cellular immunopheto type and regenerative capacity are different in different anatomical sites.Thus,there is considerable difference in the response of SSCs to military injuries and in the underlying mechanisms.This review discussed the sources of SSCs,underlying mechanisms of SSCs-mediated skeletal regeneration,and the potential applications of SSCs in military regenerative medicine.
关键词
骨骼干细胞/军事再生医学/骨折/骨软骨缺损/放射性骨损伤Key words
skeletal stem cells/military regenerative medicine/bone fracture/osteochondral defect/radiation-induced bone injury引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据