Research progress in applicability of skeletal stem cells in military regenerative medicine
Military training and operations usually lead to such skeletal injuries as fatigue fractures,acute bone fractures,osteochondral defects,and radiation-induced bone injury.Skeletal stem cells(SSCs)are newly-identified innate tissue specific stem cells in skeletons which are capable of differentiating into bone,cartilage and bone marrow stromal tissues,and are one of the seed cells critical to the development,homeostasis,and regeneration of skeletons.SSCs are highly heterogenous in cellular subpopulations and spatiotemporal distributions,which is why their cellular immunopheto type and regenerative capacity are different in different anatomical sites.Thus,there is considerable difference in the response of SSCs to military injuries and in the underlying mechanisms.This review discussed the sources of SSCs,underlying mechanisms of SSCs-mediated skeletal regeneration,and the potential applications of SSCs in military regenerative medicine.
skeletal stem cellsmilitary regenerative medicinebone fractureosteochondral defectradiation-induced bone injury
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