首页|膨润土对海藻酸钠/壳聚糖凝胶微球性能的影响

膨润土对海藻酸钠/壳聚糖凝胶微球性能的影响

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为了得到一种对啶虫脒具有高负载率和良好的缓释性能的农药载体,以膨润土作为吸附剂,利用壳聚糖的成膜性,采用挤出外源凝胶法制备了啶虫脒凝胶微球.并通过FTIR、SEM、TG、溶胀实验和释药实验对其结构、形貌和性能进行表征.结果表明,所制得的凝胶微球的粒径为1.42～1.71 mm,膨润土可提高微球粒径与球形度,使啶虫脒的载药率和包封率分别由原来的4.16％和36.36％提升为4.91％和63.01％.壳聚糖与海藻酸钠通过静电作用形成了聚电解质复合物,辅助了钙离子交联,使啶虫脒的载药率和包封率分别由原来的4.16％和36.36％提升为5.23％和54.29％.膨润土表面含有大量的羟基,与海藻酸钠和壳聚糖形成氢键作用,可有效抑制海藻酸钙的大量溶胀,提高其缓释性能.
Influence of Bentonite on the Performance of Sodium Alginate-Chitosan Hydrogel Beads
To obtain an acetamiprid pesticide carrier with high loading rate and good sustained-release properties, the acetamiprid hydrogel beads were prepared by the extrusion-exogenous gelation method, using bentonite as adsorbent and taking advantage of the film-forming properties of chitosan. The structure, morphology and performance of those hydrogel beads were characterized by means of Fourier transform infrared spectroscopy(FTIR) .scanning electron micrograph(SEM) ,thermogravimetry(TG) , water-up tests and release studies. The experimental results show that the obtained hydrogel beads were 1.42 ~ 1.71 mm in diameter. Bentonite could improve the hydrogel beads' size and sphericity and enable the drug loading rate and encapsulation efficiency of acetamiprid to increase from 4. 16% and 36. 36% to 4. 91% and 63. 01% Respectively. Chitosan and sodium alginate had formed poly electrolyte complexes by electrostatic interactions, and those complexes assisted the crosslinking by calcium ion and made the drug loading rate and encapsulation efficiency of acetamiprid increase from 4. 16% and 36. 36% to 5. 23% and 54. 29% , respectively. Bentonite contains a lot of hydroxyl groups on the surface that could form the hydrogen bonds with the sodium alginate and chitosan, which could effectively inhibit the mass swelling of calcium alginate so as to improve their release performance.

bentonitesodium alginatechitosanacetamipridhydrogel beadsdrug loading rateencapsulation efficiencysustained-release effectfunctional materials

颜慧琼、李嘉诚、冯玉红、胡文涛、牛迪、林强

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海南大学材料与化工学院化工系,海南海口570228

海南师范大学,海南海口571100

膨润土 海藻酸钠 壳聚糖 啶虫脒 凝胶微球 载药率 包封率 缓释性能 功能材料

"十二五"国家科技支撑计划资助项目"十二五"国家科技支撑计划资助项目海南省重点科技计划海口市重点科技计划项目

2011BAE06A06-72011BAE06B04-7ZDXM201200032011-0104

2013

精细化工
大连化工研究院设计院 中国化工学会精细化工专业委员会 辽宁省化工研究院

精细化工

CSTPCDCSCD北大核心
影响因子：0.557
ISSN：1003-5214
年,卷(期)：2013.30(2)
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