羧甲基壳聚糖-蓖麻油基聚氨酯农药缓释微球的制备及性能
Preparation and properties of carboxymethyl chitosan-castor oil-based polyurethane pesticide sustained-release microspheres
范燕香 1周红军 1周新华 1黄雪1
作者信息
- 1. 仲恺农业工程学院 化学化工学院,广东 广州 510225
- 折叠
摘要
以羧甲基壳聚糖(CMCS)、蓖麻油(CO)和异佛尔酮二异氰酸酯(IPDI)为原料,通过自乳化法制备了羧甲基壳聚糖-蓖麻油基聚氨酯微球(CO-CMCS-PU),通过分子自组装法负载阿维菌素(AVM)得到载药微球(CO-CMCS-PU@AVM).采用 FTIR、1HNMR、SEM、TGA 对产品结构及形貌进行了表征,并探究了不同药量载药微球的包封率、缓释性能、抗紫外性能、叶面接触角和黏附性能.结果表明,相比 AVM 分散液,紫外光照射后载药微球中AVM的保留率提高到43%以上,说明CO-CMCS-PU载体的抗紫外性能良好;载药微球溶液比AVM分散液在黄瓜叶面上的接触角降低了 21%以上,滞留量提高了 40%以上,说明其在叶面上有较好的黏附性和润湿性;载药微球包封率可达82%以上,具有良好的缓释和pH响应释放性能,释药行为符合First-order动力学模型和Korsmeyer Peppas模型,药物释放受Fickian扩散控制.
Abstract
Carboxymethyl chitosan(CMCS)-castor oil(CO)-based polyurethane(PU)microspheres(CO-CMCS-PU)were prepared from self-emulsification of CMCS,CO and isophorone diisocyanate(IPDI),and avermectin(AVM)drug-loaded microspheres(CO-CMCS-PU@AVM)were obtained by molecular self-assembly.The structure and morphology of the products obtained were characterized by FTIR,1HNMR,SEM and TGA,while the encapsulation efficiency,slow-release performance,anti-ultraviolet performance,leaf contact angle and adhesion performance of drug-loaded microspheres with different drug doasage were explored.The results showed that,compared with AVM dispersion,AVM-loaded microspheres solutions exhibited good ultraviolet resistance with an increased AVM retention rate of over 43%after ultraviolet irradiation,good adhesion and wettability on cucumber leaves with a decrease in the contact angle on cucumber leave by>21%and an increase in retention capacity by>40%,and good slow-release and pH-responsive release performance with the encapsulation efficiency>82%.The drug release behavior conformed to the First-order kinetic model and Korsmeyer Peppas model,while the drug release was controlled by Fickian diffusion.
关键词
羧甲基壳聚糖/蓖麻油/聚氨酯/缓释/pH响应/功能材料Key words
carboxymethyl chitosan/castor oil/polyurethane/sustained release/pH response/functional materials引用本文复制引用
基金项目
广东省普通高等学校重点领域专项(2021ZDZX2056)
广州市科技计划(201904010087)
大学生创新创业训练计划(202111347022)
大学生创新创业训练计划(X202211347363)
大学生创新创业训练计划(X202211347376)
出版年
2024
NETL
NSTL
维普
万方数据