首页|羧甲基壳聚糖-蓖麻油基聚氨酯农药缓释微球的制备及性能

羧甲基壳聚糖-蓖麻油基聚氨酯农药缓释微球的制备及性能

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  • NETL
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以羧甲基壳聚糖(CMCS)、蓖麻油(CO)和异佛尔酮二异氰酸酯(IPDI)为原料,通过自乳化法制备了羧甲基壳聚糖-蓖麻油基聚氨酯微球(CO-CMCS-PU),通过分子自组装法负载阿维菌素(AVM)得到载药微球(CO-CMCS-PU@AVM).采用 FTIR、1HNMR、SEM、TGA 对产品结构及形貌进行了表征,并探究了不同药量载药微球的包封率、缓释性能、抗紫外性能、叶面接触角和黏附性能.结果表明,相比 AVM 分散液,紫外光照射后载药微球中AVM的保留率提高到43%以上,说明CO-CMCS-PU载体的抗紫外性能良好;载药微球溶液比AVM分散液在黄瓜叶面上的接触角降低了 21%以上,滞留量提高了 40%以上,说明其在叶面上有较好的黏附性和润湿性;载药微球包封率可达82%以上,具有良好的缓释和pH响应释放性能,释药行为符合First-order动力学模型和Korsmeyer Peppas模型,药物释放受Fickian扩散控制.
Preparation and properties of carboxymethyl chitosan-castor oil-based polyurethane pesticide sustained-release microspheres
Carboxymethyl chitosan(CMCS)-castor oil(CO)-based polyurethane(PU)microspheres(CO-CMCS-PU)were prepared from self-emulsification of CMCS,CO and isophorone diisocyanate(IPDI),and avermectin(AVM)drug-loaded microspheres(CO-CMCS-PU@AVM)were obtained by molecular self-assembly.The structure and morphology of the products obtained were characterized by FTIR,1HNMR,SEM and TGA,while the encapsulation efficiency,slow-release performance,anti-ultraviolet performance,leaf contact angle and adhesion performance of drug-loaded microspheres with different drug doasage were explored.The results showed that,compared with AVM dispersion,AVM-loaded microspheres solutions exhibited good ultraviolet resistance with an increased AVM retention rate of over 43%after ultraviolet irradiation,good adhesion and wettability on cucumber leaves with a decrease in the contact angle on cucumber leave by>21%and an increase in retention capacity by>40%,and good slow-release and pH-responsive release performance with the encapsulation efficiency>82%.The drug release behavior conformed to the First-order kinetic model and Korsmeyer Peppas model,while the drug release was controlled by Fickian diffusion.

carboxymethyl chitosancastor oilpolyurethanesustained releasepH responsefunctional materials

范燕香、周红军、周新华、黄雪

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仲恺农业工程学院 化学化工学院,广东 广州 510225

羧甲基壳聚糖 蓖麻油 聚氨酯 缓释 pH响应 功能材料

广东省普通高等学校重点领域专项广州市科技计划大学生创新创业训练计划大学生创新创业训练计划大学生创新创业训练计划

2021ZDZX2056201904010087202111347022X202211347363X202211347376

2024

10.13550/j.jxhg.20230351

精细化工
大连化工研究院设计院 中国化工学会精细化工专业委员会 辽宁省化工研究院

精细化工

CSTPCD北大核心
影响因子：0.557
ISSN：1003-5214
年,卷(期)：2024.41(1)
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