Effect of Rosa roxburghii Tratt.extract on hyperuricemia rats by metabonomics
Hyperuricemia rat models,established with potassium oxonate,were administered with low,medium and high doses of Rosa roxburghii Tratt.extract as well as allopurinol(positive drug control).Non-targeted qualitative analysis on rat serum was performed using LC-MS technology,with multivariate statistical methods used to analyze rat serum data and screen for differential metabolites.Metabolic pathway analysis was further conducted via the MBRole 2.0 pathway analysis function.The results showed that all dosage of Rosa roxburghii Tratt.extract could reduce uric acid concentration in serum of hyperuricemia rats,and 242 metabolites were identified in the serum.Under the criteria of variable importance projection(VIP)>1,P<0.01,and fold change(FC)≥2,a total of 44 significantly different metabolites were screened,with a total of 58 metabolic pathways corresponding to different metabolites.The reduction of uric acid by Rosa roxburghii Tratt.extract might be related to its inhibition of xanthine oxidase activity and regulation of serum lipid and amino acid metabolism.
Rosa roxburghii Tratt.extracthyperuricemianontargeted metabolomicsdifferential metabolitesmetabolic pathwaymodern technology of Chinese medicine
NETL
NSTL
万方数据
维普
