随着中国老龄化社会进程加快,以及疾病和交通事故等因素的影响,骨损伤病例呈逐年增加趋势,使骨替代材料的市场需求不断扩大.羟基磷灰石(HA)具有优异的生物活性和生物相容性,是人类和动物骨骼的主要组成成分,在生物体内可降解、参与代谢,释放出的离子对机体无害,被广泛应用于骨修复、再生和置换等骨组织工程,但HA纳米粒子分散性差、强度低、高分子相容性差等缺点,限制了其应用.为了克服这些缺点,探索改性或复合 HA 的方法,以改善其分散性、亲水性、抗菌性及机械强度等,来满足临床应用的要求.该文重点总结了当前主流的 HA 纳米粒子的改性方法,包括离子掺杂、表面改性、材料复合.详细介绍了目前 HA复合材料的研究热点,以期为HA复合材料相关基础研究提供有益的借鉴与启示.
Research progress on modified hydroxyapatite nanoparticles for bone tissue engineering
With the acceleration of China's aging society and other influence factors like diseases,traffic accidents,the bone injury cases are increasing year after year,resulting in expanded market demand for bone replacement materials.Hydroxyapatite(HA),the main component of human and animal bones with excellent biological activity and biocompatibility,can be degraded in the organism,participate in metabolism,releases ions that are harmless to the body,and has been widely used in bone tissue engineering for bone repair,regeneration,or replacement.However,its applications are restricted due to the disadvantages of poor dispersion,low strength,poor polymer compatibility,and others.Researches are focused on HA modification or compounding for improvement in its dispersibility,hydrophilicity,antibacterial capabilities,and mechanical strength to satisfy the requirements of therapeutic applications.Herein,the mainstream HA nanoparticle modification methods,including ion doping,surface modification and materials compositing were summarized.Finally,the current research hotspots of HA composites were discussed in detail,in order to provide useful reference and enlightenment for basic research on HA composites.
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