Electrospun preparation and characterization of perillaldehyde/methyl-β-cyclodextrin inclusion complex nanofiber
To improve the thermal stability and water solubility of perillaldehyde(PA)and expand its application,PA/methyl-β-cyclodextrin(MβCD)inclusion complex(PA/MβCD-IC)nanofiber(PA/MβCD-IC-NF)was prepared from host molecule MβCD and guest molecule PA by electrospinning technology.The obtained samples was then characterized by SEM,1HNMR,XRD,TGA,FTIR and molecular simulation.The PA/MβCD-IC-NF was further analyzed and evaluated for its phase solubility and those antioxidant and antibacterial properties.The results showed that PA/MβCD-IC was successfully formed with PA encapsulated in the MβCD cavity,while PA/MβCD-IC-NF exhibited an amorphous structure with a uniform diameter distribution and smooth surface,with an average diameter of(134±60)nm.PA/MβCD-IC-NF(2 cm×2 cm)with a mass concentration of 12 g/L could be completely dissolved within 1 s.Compared with those of PA,the thermal stability and water solubility of PA were significantly enhanced after the formation of PA/MβCD-IC-NF.The antioxidant activity of PA/MβCD-IC-NF was significantly higher than that of PA,with the inhibition rates against Escherichia coli and Staphylococcus aureus of 96.2%±0.1%and 94.0%±0.3%,respectively.