静电纺丝紫苏醛/甲基-β-环糊精包合物纳米纤维的制备与表征
Electrospun preparation and characterization of perillaldehyde/methyl-β-cyclodextrin inclusion complex nanofiber
张杨 1李晓明 1胡芬 1高爽1
作者信息
- 1. 东北农业大学 文理学院,黑龙江 哈尔滨 150030
- 折叠
摘要
为提高紫苏醛(PA)的热稳定性和水溶性,扩展其应用,以甲基-β-环糊精(MβCD)为主体分子,PA为客体分子,通过静电纺丝技术制备了PA/MβCD包合物(PA/MβCD-IC)纳米纤维(PA/MβCD-IC-NF).采用 SEM、1HNMR、XRD、TGA、FTIR 和分子模拟对 PA/MβCD-IC-NF 进行了表征和分析,测试了其相溶解度,评价了其抗氧化活性和抑菌性能.结果表明,PA已被成功地包裹在MβCD空腔中,形成PA/MβCD包合物;PA/MβCD-IC-NF 为非晶体结构,直径分布较均匀且表面光滑,平均直径为(134±60)nm.质量浓度为 12 g/L的PA/MβCD-IC-NF(2 cm×2 cm)在 1 s内可完全溶解.与PA相比,PA/MβCD-IC-NF中PA的热稳定性和水溶性都显著提高.PA/MβCD-IC-NF 的抗氧化活性明显高于 PA,对大肠杆菌与金黄色葡萄球菌的抑制率分别为 96.2%±0.1%和 94.0%±0.3%.
Abstract
To improve the thermal stability and water solubility of perillaldehyde(PA)and expand its application,PA/methyl-β-cyclodextrin(MβCD)inclusion complex(PA/MβCD-IC)nanofiber(PA/MβCD-IC-NF)was prepared from host molecule MβCD and guest molecule PA by electrospinning technology.The obtained samples was then characterized by SEM,1HNMR,XRD,TGA,FTIR and molecular simulation.The PA/MβCD-IC-NF was further analyzed and evaluated for its phase solubility and those antioxidant and antibacterial properties.The results showed that PA/MβCD-IC was successfully formed with PA encapsulated in the MβCD cavity,while PA/MβCD-IC-NF exhibited an amorphous structure with a uniform diameter distribution and smooth surface,with an average diameter of(134±60)nm.PA/MβCD-IC-NF(2 cm×2 cm)with a mass concentration of 12 g/L could be completely dissolved within 1 s.Compared with those of PA,the thermal stability and water solubility of PA were significantly enhanced after the formation of PA/MβCD-IC-NF.The antioxidant activity of PA/MβCD-IC-NF was significantly higher than that of PA,with the inhibition rates against Escherichia coli and Staphylococcus aureus of 96.2%±0.1%and 94.0%±0.3%,respectively.
关键词
静电纺丝/紫苏醛/甲基-β-环糊精/包合物/纳米纤维/功能材料Key words
electrospinning/perillaldehyde/methyl-β-cyclodextrin/inclusion complex/nanofibers/functional materials引用本文复制引用
基金项目
黑龙江省SIPT大学生创新实践训练计划(S202210224104)
东北农业大学SIPT大学生创新实践训练计划(X202210224120)
黑龙江省博士后科研启动基金(LBH-Q21076)
出版年
2024
NETL
NSTL
万方数据