卟啉基金属有机框架在光疗领域的应用
Porphyrinoid-based metal-organic framework for phototherapy application
徐赟浩 1邓文博 1冯亚青 2张宝2
作者信息
- 1. 天津大学 化工学院,天津 300350
- 2. 天津大学 化工学院,天津 300350;天津化学化工协同创新中心,天津 300072;物质绿色创造与制造海河实验室,天津 300192
- 折叠
摘要
卟啉基金属有机框架是金属或金属团簇与卟啉配体或其家族化合物配位自组装形成的晶体结构,结合了卟啉类分子良好的光物理特性和生物相容性,具有周期性和可调控的结构,在光化学领域和生物医药领域具有应用潜力;尤其是能够充分发挥卟啉类分子的优越性能,可通过光动、光热等光辅助治疗方法实现杀伤有害细胞的效果.该文介绍了卟啉基金属有机框架的结构,综述了卟啉基金属有机框架在光辅助治疗领域的最新研究进展,主要包括其在光疗抗肿瘤及抗菌领域的应用研究现状,重点介绍了近几年卟啉基金属有机框架在光敏剂基础上的改进以及衍生出的多样化的功能;最后,对其未来发展前景进行了展望.
Abstract
Porphyrinoid-based metal organic framework,featured with a crystal structure formed by the coordinating self-assembly between metal clusters and porphyrin ligand or porphyrinoid family compounds,has shown promising application potential in the field of photochemistry and biological medicine due to its combination of good photophysical properties and biocompatibility of porphyrinoid molecules as well as its periodic and controllable structure.In particular,with the excellent performance of porphyrinoid molecules fully utilized,the porphyrinoid metal organic framework plays an important role in killing harmful cells in human bodies with adjunctive photo-assisted therapy including photokinetic and photothermal treatments.Herein,the structure of porphyrinoid-based metal organic framework was introduced,followed by summarization on the recent development of porphyrinoid-based metal organic framework in the biomedical field including anti-tumor and anti-bacterial treatments.The performance improvement of porphyrinoid-based metal organic framework type photosensitizers in comparison to porphyrinoid molecules,and the diverse functions derived from the different type of porphyrinoid metal organic framework were emphatically discussed.Finally,the future development potentials of porphyrinoid metal organic framework were also proposed.
关键词
卟啉/金属有机框架/光辅助治疗/抗肿瘤/抗菌性能Key words
porphyrinoid/metal organic frameworks/photo-assisted therapy/anti-tumor/anti-bacterial properties引用本文复制引用
基金项目
国家自然科学基金(22078241)
中央高校基本科研业务费专项()
物质绿色创造与制作海河实验室项目()
出版年
2024
NETL
NSTL
万方数据