Research progress in effect of MOFs pore structure on properties of immobilized enzymes
Enzyme immobilization is an effective approach to promote its industrial applications,with the carrier the key influencing factor on the catalytic performance of immobilized enzymes.Metal-organic frameworks(MOFs),highly ordered porous materials with clear structure-function relationships,uniform pore size distribution,tunable and designable porosity at the atomic level,have made significant progress as enzyme carrier.This review focused on the influence of MOFs pore structure on their enzyme immobilization performance.Herein,the influencing factors on MOFs pore structure were analyzed,followed by research progress summarization on enzyme loading in cage-type cavities and channel-type pores with a detailed description on the influence of porosity on enzyme immobilization,enzyme activity etc.Finally,the special role of MOFs hierarchical-structure in enhancing mass transfer with immobilized enzymes and the importance of developing pore-enzyme matching MOFs were pointed out,while the development advantages of utilizing MOFs autocatalytic ability to construct high-efficiency chemical-enzyme cascade catalysts in nanometer scale and the feasibility of enhancing enzyme catalytic process by regulating microenvironment were discussed.
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