Polysaccharides-based thermosensitive injectable hydrogels,a class of smart soft-matter materials which are capable of achieving reversible liquid-solid transition under temperature stimuli and show the advantages of high biocompatibility,biodegradability,and tunable physical and chemical properties,have attracted wide attention in the biomedical field.Herein,the sol-gel phase transition mechanism of thermosensitive injectable hydrogels was summarized.The strategies for design and synthesis of polysaccharides-based thermosensitive injectable hydrogels,including small molecule group modified polysaccharides,synthetic thermosensitive polymer grafted polysaccharides,additive modified polysaccharides,were described.The applications of polysaccharides-based thermosensitive injectable hydrogels in the biomedical field such as wound healing,drug delivery and cartilage repair were reviewed.The challenges of optimizing raw material composition and design strategy,developing diversified environmental stimulus responses,and enhancing mechanical strength and stability were also discussed.Finally,the prospect of expanding the application scope of polysaccharide-based hydrogel and accelerating their wide-scale clinical application was proposed.
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