Synthesis and antibacterial activities of osthole aromatic acrylate derivatives
On the basis of previous research on osthole,twenty-four ester derivatives were designed and synthesized from combination of advantageous structure of osthole with aromatic acrylic acids,with their structures confirmed by 1HNMR,13CNMR and elemental analysis.Data from antibacterial activity analysis showed that(E,E)-4-nitrophenylacrylic acid[(7-methoxy-2-oxo-2H-chromoene-8-yl)-3-methyl-2-butene]ester(Ⅲ h)and(E,E)-thiazole-2-acrylic[(7-methoxy-2-oxo-2H-chromoene-8-yl)-3-methyl-2-butene]ester(Ⅲ t)displayed the most significant antibacterial effect,with the minimum inhibitory concentrations(MIC)of compound Ⅲh against Staphylococcus aureus(S.aureus),Escherichia coli(E.coli),methicillin-resistant Staphylococcus aureus(MRSA)and fluoroquinolone-resistant Escherichia coli(FREC)of 4,16,8 and 16 mg/L,respectively,while those of Ⅲ t of 2,8,4,8 mg/L,respectively.Their inhibitory activities against the tested bacteria were better than those of previous compounds,showing potential research value.
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