Correlation analysis of influencing factors of cervical high-risk HPV infection in postmenopausal women
Objective This study aims to analyze the relevant influencing factors of cervical HPV infection in postmenopausal women.Methods Retrospective analysis was conducted on postmenopausal women who underwent high-risk HPV screening in The First Affiliated Hospital of Nanchang University from January 2021 to December 2022.They were divided into high-risk HPV positive group and HPV negative group based on whether they were high-risk HPV positive or not.Collect data on age,menopausal age,BMI,number of pregnancies,number of natural deliveries,vaginal secretions,cervical diseases,gynecological dis-eases,breast diseases,autoimmune diseases,aginal microecology(vaginal abnormal pH,leanliness,and Lactobacillus),and other factors for all included population in the study.Compare the differences between the two groups of aforementioned factors and ana-lyze the correlation between each factor and high-risk HPV infection through logistic regression.Results In univariate analysis,menopausal age,cervical diseases,vaginal abnormal Lactobacillus,and autoimmune diseases were correlated with high-risk HPV infection(P<0.05).BMI,pregnancy times,spontaneous labor times,vaginal secretions,gynecological diseases,breast diseases,vagi-nal abnormal pH,and leanliness etc.did not show any correlation with high-risk HPV infection(P>0.05).Multivariate logistic re-gression analysis showed a significant correlation between postmenopausal age,cervical diseases,and vaginal abnormal Lactobacil-lus and the occurrence of high-risk HPV infection after menopause(P<0.05).Conclusion The age of menopause is independently related to cervical lesions and high-risk HPV infection.In clinical practice,it is necessary to strengthen high-risk HPV screening for postmenopausal women,cervical lesions,and vaginal Lactobacillus.At the same time,it is necessary to focus on screening for HPV infection in patients with early menopausal age to detect adverse cervical changes in the early stage.
postmenopausal womenhuman papillomaviruscervical cancer
万方数据
维普
