Diagnostic value of MMP25 and E-cadherin in rheumatoid arthritis
Objective To investigate the diagnostic significance of Matrix metalloproteinase 25(MMP25)and E-cadherin in rheumatoid arthritis.Methods 67 patients with rheumatoid arthritis in our hospital from January 2020 to October 2023 were cho-sen as the experimental group,and 50 healthy people during the same period were chosen as the control group.The serum levels of MMP25 and E-cadherin were detected by enzyme-linked immunosorbent assay(ELISA).The indexes of ESR,CRP,CCP,RF,DAS28-ESR and DAS28-CRP were collected from patients in the experimental group,as well as whether they were newly diag-nosed,whether they had complications(anemia,interstitial pneumonia,etc),disease course and clinical activity grade and correla-tion with MMP25 and E-cadherin levels were analyzed.Results The serum levels of MMP25 and E-cadherin in rheumatoid arthritis patients were higher than those in control group,with statistical significance(P<0.001).Scatter plot and simple linear re-gression analysis with ESR,CRP,CCP and RF showed that there were significant differences in the expression of MMP25 in differ-ent clinical activity groups(P<0.001),MMP25 and disease course(β=0.479,P<0.001),MMP25 and CRP(β=0.271,P<0.05),MMP25 and DAS28-ESR(β=0.660,P<0.001)and MMP25 and DAS28-CRP(β=0.624,P<0.001)are all correlated;There were significant differences there were significant differences in the expression of E-cadherin in different clinical activity groups(P<0.001),E-cadherin and ESR(β=0.425,P<0.001),E-cadherin and CRP(β=0.328,P<0.05),E-cadherin and DAS28-ESR(β=0.746,P<0.001),E-cadherin and DAS28-CRP(β=0.671,P<0.001).The results of multiple linear regression analysis showed that the expression level of MMP25 was positively correlated with clinical activity(β=1.032,P<0.001),the expression level of E-cadherin was positively correlated with clinical activity(β=0.407,P<0.05),and the duration of disease(β=0.497,P<0.001).Conclusion The expression level of MMP25 and E-cadherin can be used as markers to evaluate clinical activity in rheumatoid arthritis,and the expression level of E-cadherin can also measure the duration of disease.
MMP25E-cadherinRheumatoid arthritisDiagnostic value
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