The expression of PD1/PD-L1,neutrophil elastase and lysyl oxidase in bladder cancer and their relationship with the prognosis of bladder cancer
Objective To investigate the expression levels of programmed cell death receptor 1(PD1),programmed cell death ligand 1(PD-L1),neutrophil elastase(NE)and lysyl oxidase(LOX)in bladder cancer and their relationship with clinicopathologic features and prognosis.Methods Cancer tissues of 56 patients with bladder cancer admitted to Jiangxi Provincial People's Hospital from January 2018 to December 2020 were selected as the study objects.During the follow-up period,recurrence and death of pa-tients were recorded.Immunohistochemical staining was used to detect the expressions of PD1,PD-L1,NE and LOX,and to ana-lyze the relationship between PD1,PD-L1,NE and LOX and the clinicopathologic features and prognosis of patients with bladder cancer.Results Immunohistochemical results showed that PD1 was expressed in tumor-related immune cells(46/56).The positive expression rate of PD1 in tumor tissues of patients with T2-T3 TNM stage was higher than that of patients with Tis-T1 stage,the positive expression rate of PD1 in patients with high-grade tumor was higher than that in patients with low-grade tumor,and the positive expression rate of PD1 in patients with lymph node metastasis was higher than that in patients without metastasis(P＜0.05).The positive expression rate of PD-L1 in patients with T2-T3 TNM stage was higher than that in patients with Tis-T1 stage,and the positive expression rate of PD-L1 in patients with lymph node metastasis was higher than that in patients without metastasis(P＜0.05).NE was positively correlated with the expression of PD1 and PDL-1(P＜0.05).LOX was positively correlated with the ex-pression of PD-L1 and PDL-1(P＜0.05).The 3-year progression-free survival rate was 58.70%(27/46)in patients with PD1 posi-tive expression,and 43.48%(10/23)in patients with PD-L1 positive expression.The 3-year progression-free survival rate of pa-tients with different PD1 and PD-L1 expression was significantly different(P＜0.05).Conclusion The increased expression of PD1 and PD-L1 in bladder cancer can be used as potential prognostic indicators for patients with bladder cancer,which can help to screen high-risk patients with postoperative recurrence and provide a new target for the immunological treatment of bladder cancer.
bladder cancerProgrammed cell death receptor 1Programmed cell death ligand 1Tumor-associated neutrophil factor
万方数据
维普
