Study on the dose-response relationship of the antitussive effect of Camellia oleifera saponins evaluated by a biological signal collection system combined with artificial observation
Objective To establish a biological signal collection system combined with artificial visual observation to evaluate the dose-response relationship of the cough suppressive effect of Camellia oleifera saponins.Methods A biological signal acquisi-tion system was used to evaluate the effect of changes in the dosage of Camellia oleifera saponin on the number of coughs and cough latency in guinea pigs,using respiratory wave amplitude change rate combined with artificial visual observation.The dose-re-sponse relationship equation of Camellia oleifera saponin for cough suppression was obtained through multiple linear regression.Results Compared with normal respiratory waves,the average amplitude change rate of the first cough wave was 2 335%,and the last one was 125%.The same dose of Camellia oleifera saponin 75、100、175、200 mg/kg can significantly reduce the number of coughs in guinea pigs(P＜0.05),and the regression equation is y=54.4576-0.2693x+0.0011x2.The same dose of 75、100、125、175、225 mg/kg can significantly prolong the cough latency in guinea pigs(P＜0.05),with a regression equation of y=27.1679-0.4169x+0.0014x2.Conclusion The combination of biological signal acquisition system and artificial visual observation can ob-jectively evaluate the dose-response relationship of Camellia oleifera saponin in relieving cough.The experiment shows that there is a non-linear relationship between the dosage of Camellia oleifera saponin and its antitussive effect.
Camellia oleifera saponinsAnticough effectBiological signal acquisition systemQuantity effect relationship
万方数据
维普
