Study on the Protective Effect of Papaverine on Intestinal Injury in Traumatic Shock Rats
Objective To study the protective effect of papaverine on intestinal injury in traumatic shock rats.Methods Twenty SD rats were selected and randomly divided into two groups.The control group established a traumatic shock rat model us-ing the femoral trauma method,and after modeling,routine fluid resuscitation was performed.The experimental group received 1.5mg/kg papaverine and 50ml physiological saline micro pump for continuous injection for 24 hours on the basis of the control group.After 24 hours,blood was drawn to detect serum intestinal fatty acid binding protein(IFABP),Diamine oxidase(DAO)and inflammatory factor TNF-α,IL-6 Concentration.Results 1.The concentration of serum IFABP,DAO and inflammatory factor TNF-α,IL-6 in rats with traumatic shock after 24 hours significantly increased.2.After intervention with papaverine,the concentration of serum IFABP,DAO and inflammatory factor TNF-α,IL-6 in rats was significantly reduced compared to the control group.Con-clusion Papaverine can alleviate intestinal injury and reduce systemic inflammatory response in traumatic shock rats.
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