Objective To investigate the effects of a high whey protein substitute diet on blood glucose and lipid levels in a rat model of high-fat diabetes.Methods Fifty female rats were randomly assigned to a normal control group of 10 and a model group of 40.The model group weer fed on high-fat and high-sugar diet for 30 days,followed by an injection of STZ.After inducing diabetes,the rats were randomly divided into model control,low-dose,medium-dose,and high-dose groups,received diets for 30 days with normal diets and whey protein comprising 25%,35%,and 45%of total caloric intake,respectively.Results After 30 days on the high-protein substitute diet,the high-dose group exhibited a significant weight loss(P＜0.05);the medium-dose group showed marked improvements in lipid and glucose parameters(TC,TG,HDL,LDL,Glu,FINS);the high-dose group also saw sig-nificant reductions in weight,TC,TG as well as Glu and FINS levels(P＜0.05),with the decreases in Glu and FINS for the medium and high-dose groups being greater than those in the model control group(P＜0.05).Conclusion Substituting carbohydrates with whey protein effectively reduces body weight,blood lipids,and blood glucose levels in high-lipid diabetic female rats.
Diabetes modelWhey protein substitute dietBlood sugarBlood lipid
NETL
NSTL
万方数据
