Objective This study aimed to explore the potential of curcumin in mitigating postoperative cognitive dysfunction(POCD)in aged rats by modulating the release of inflammatory mediators.Methods A total of 48 aged Sprague-Dawley rats were randomly assigned to four groups(n=12 each):a control group(Group S),a POCD model group(Group POCD),a curcumin treat-ment group(Group C),and a combination of curcumin treatment and POCD induction group(Group C+POCD).Groups C and C+POCD received 300 mg/kg of curcumin orally for two weeks.Rats in Groups POCD and C+POCD were subjected to 3%sevoflurane anesthesia followed by sham abdominal surgery to induce POCD.Postoperative behavioral assessments and hippocampal neuronal cell analysis were conducted.Additionally,hippocampal levels of neuromediators were quantified.Results Compared to Group S,Group POCD exhibited significant declines in memory and learning,disorganization of hippocampal neurons,extensive neuronal necrosis,and increased levels of TNF-alpha and IL-6 in the hippocampus.Conversely,Group C+POCD showed significant im-provements in memory and learning,reduced hippocampal neuronal damage,and decreased levels of TNF-alpha and IL-6,with an increase in IL-10 levels.Conclusion Curcumin effectively ameliorates postoperative cognitive dysfunction in aged rats by reduc-ing the inflammatory response in the central nervous system.These findings suggest that curcumin could be a potential therapeutic agent for preventing POCD in clinical settings.
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