The effect on hemodynamics in elderly patients by pre-injection of different doses of esketamine during the induction pe-riod of general anesthesia
Objective To explore the effect on hemodynamics in elderly patients by pre-injection of different doses of eske-tamine during the induction period of general anesthesia.Methods 80 elderly patients aged 65～75 who underwent eye operations in our hospital were selected and randomly divided into four groups with 20 cases each,according to the random number table method.The control group was given conventional induction(N group);Three observer groups:group S1 was given 0.2 mg/kg eske-tamine,group S2 was given 0.4 mg/kg esketamine,and group S3 was 0.6 mg/kg esketamine.The control group received intravenous injection of sufentanil 3 μg/kg,propofol 1.5 mg/kg,and cisatracurium 0.2 mg/kg;observation group S1,S2,and S3 were respec-tively given intravenous injection of eskatamine 0.2 mg/kg,0.4 mg/kg,0.6 mg/kg before induction of general anesthesia,then the same drugs as the control group were injected intravenously sequentially.Arterial pressure(MAP)and heart rate(HR)were record-ed,before induction(T0),2 min after induction(T1),at the moment of intubation(T2),at 1 min(T3),3 min(T4),10 min(T5)after in-tubation.Results Compered with the group N,HR in group S1,S2 at T4 were obviously higher and MAP at T1,T2,T3,T4 were ob-viously higher.Compered with group N,group S1,S2,MAP and HR in group S3 at T1,T2,T3,T4 were obviously higher and HR at T5 were obviously higher(P<0.05).There was no statistically significant difference in the incidence rates of nausea,vomiting,and postoperative agitation among the four groups(P<0.05).The number of cases of dopamine use in group N was significantly greater than that in groups S1,S2,and S3(P<0.05),and the difference was statistically significant.Conclusion Compared with the pre-in-jection of eskatamine 0.2 mg/kg or 0.4 mg/kg and 0.6 mg/kg during the induction period of general anesthesia in elderly patients,it avoids severe fluctuations in hemodynamics and does not increase side effects such as nausea and vomiting.The use of ketamine provides a certain reference.
esketamineagedinduction of general anesthesiastress response
万方数据
维普
