Progress in the study of the role of programmed death in pulmonary hypertension syndrome(PH)in broiler chickens
Pulmonary hypertension syndrome(PH)in broilers is a nutritional and metabolic disease often occurring in fast and large broilers,and its pathological manifestations are mainly the presence of large fluid retention in the abdomen,re-modelling of the pulmonary arteries and a decrease in exercise tolerance,resulting in significant economic losses,and so it is a disease needing to be focused on and solved in the current poultry farming industry.Programmed death is a genetically regulated,active and orderly way of cell death involved in numerous physiological and pathological processes.Programmed death plays an integral role in the pathogenesis of PH,mediating numerous cardiovascular pathobiological processes and influencing the development of pulmonary artery remodeling.Taking programmed death as an entry point,the paper introduces and summarizes relevant studies on programmed death and PH,focusing on the mechanism by which programmed death regulates the development of PH by mediating the proliferation and differentiation of pulmonary artery smooth muscle cells(PASMCs)and pulmonary artery endothelial cells(PAECs),so as to explain the molecular mechanism of PH pathogenesis from the perspective of programmed death and to provide an opportunity for the development of PH by targeting programmed death.The paper aims to explain the molecular mechanism of PH pathogenesis from the perspective of programmed death and to provide new references for the clinical prevention and treatment of PH and drug development targeting programmed death.
pulmonary hypertension syndrome(PH)in broilershypoxiapulmonary artery re-modellingPASMCsPAECsprogrammed death
万方数据
维普
