微生物-肠-脑轴在抽动障碍中的作用研究进展
Research advances in role of microbiota-gut-brain axis in tic disorders
梁妍 1万林 1闫会敏 1刘欣婷 1朱刚 1张璟 1杨光1
作者信息
- 1. 解放军总医院第七医学中心儿科医学部,北京 100010
- 折叠
摘要
抽动障碍在儿童中的发病率逐渐升高,且常合并共患病,影响儿童的心理和日常生活.抽动障碍的病因尚不明确,当前主流学说认为神经生化因素参与抽动障碍的发生.近年来随着微生物-肠-脑轴概念的提出,有学者认为微生物参与调控包括抽动障碍等多种神经系统疾病的发生.本文就微生物-肠-脑轴在抽动障碍中的调控作用以及微生物相关制剂治疗抽动障碍的相关进展进行总结,以期促进抽动障碍发病机制和治疗方案的研究工作.
Abstract
The prevalence of tic disorders in children is gradually increasing,often accompanied by comorbidities,which has a significant impact on their psychological well-being and daily life.The etiology of tic disorders remains unclear,although current mainstream theories suggest the involvement of neurobiochemical factors in their development.In recent years,with the emergence of the concept of microbiota-gut-brain axis,it has been proposed that the microbiota plays a role in regulating the occurrence of various neurological disorders,including tic disorders.This article summarizes the regulatory role of microbiota-gut-brain axis in tic disorders and provides an overview of the progress in the use of microbiota-related preparations for tic disorders treatment,aiming to promote further research on the pathogenesis and treatment strategies for tic disorders.
关键词
抽动障碍/肠道微生物组/益生菌/微生物-肠-脑轴/粪便微生物群移植Key words
tic disorders/gastrointestinal microbiome/probiotics/microbial-gut-brain-axis/fecal microbiota transplant引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据