Research advances in multi-omics and treatment in neurofibromatosis type 2
Neurofibromatosis type 2 is a common autosomal dominant hereditary disorder caused by mutations or deletions in the NF2 gene.The disease is characterized by the growth of tumors of the central nervous system and the peripheral nervous system.Common neurofibromatosis type 2 includes bilateral vestibular schwannomas,meningiomas,ependymomas,intravertebral schwannomas,and peripheral schwannomas.Tumors associated with NF2 commonly affect multiple neural systems,significantly impacting patients'quality of life and survival.This article aims to provide an overview of NF2 based on current research progress in epidemiology,clinical characteristics,pathogenesis,genetics,correlations between NF2 gene phenotypes and disease features,and clinical management,so as to enhance our understanding of the disease's mechanisms and therapeutic strategies.
neurofibromatosis type 2clinical characteristicsepigeneticsgene mutationsclinical treatment
国家科技期刊平台
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