Research advances in clinical diagnosis of mild traumatic brain injury based on multimodal imaging
Mild traumatic brain injury(mTBI)has the characteristics of complex pathophysiology,difficulty in early diagnosis,and often accompanies by different degrees of brain dysfunction.Early intervention is required to effectively restore deficits such as attention and memory.The above-mentioned dysfunctions are closely related to the functional abnormalities of the default network,hippocampus,basal ganglia and other brain areas,and imaging can accurately quantitatively evaluate the changes in these brain functional areas,especially the emergence of high-field magnetic resonance imaging technology,which has become a key technology for early clinical diagnosis and clinical treatment evaluation of mTBI.Based on mTBI animal models and clinical patients,this paper analyzes arterial spin labeling(ASL)reflecting working memory in magnetic resonance imaging(MRI),diffusion tensor imaging(DTI)for cognitive deficits,and ultra-high-field magnetic resonance imaging for abnormal lymphatic transport.Resonance-enhanced imaging,as well as positron emission computed tomography(PET)and electroencephalography(EEG)studies that reflect the degree of traumatic brain injury are reviewed,which may provide references for military medical research of mTBI.
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