基于多模态影像学的轻度创伤性脑损伤脑功能评估的研究进展
Research advances in clinical diagnosis of mild traumatic brain injury based on multimodal imaging
倪立桐 1齐琦 1马珩钞 2曹征涛 3张玉艳 1牛田力 1官志强 1胡坚兴 1宁亚蕾 4王卫东 5马林 1李小俚 6雍政 7罗勇军 8李平 4张军 2李世俊1
作者信息
- 1. 解放军总医院第一医学中心放射诊断科,北京 100853
- 2. 解放军总医院第六医学中心神经外科,北京 100048
- 3. 空军特色医学中心,北京 100142
- 4. 陆军军医大学陆军卫勤训练基地,重庆 400038
- 5. 解放军总医院医学创新研究部,北京 100853
- 6. 北京师范大学认知神经科学与学习国家重点实验室,北京 100875
- 7. 军事科学院军事医学研究院毒物药物研究所,北京 100850
- 8. 陆军军医大学第三附属医院·野战外科研究所,重庆 400037
- 折叠
摘要
轻度创伤性脑损伤(mild traumatic brain injury,mTBI)具有病理生理复杂、早期诊断难、伴有不同程度脑功能障碍等特点,需早期干预才能有效恢复如注意力不集中、记忆力减退等脑功能障碍.上述功能障碍与大脑默认网络、海马、基底节等脑区功能异常密切关联,而影像学可以准确量化评估这些脑功能区的改变.高场强磁共振成像技术的出现,使得影像学成为mTBI临床早期诊断与临床治疗评估的关键技术.基于mTBI动物模型及临床患者,本文从磁共振成像中反映工作记忆的动脉自旋回波、反映认知缺陷的弥散张量成像、反映淋巴转运异常的超高场强磁共振增强成像以及反映颅脑冲击伤损伤程度的正电子发射计算机断层扫描术与脑电图等方面作一综述,旨在为mTBI军事医学研究提供参考.
Abstract
Mild traumatic brain injury(mTBI)has the characteristics of complex pathophysiology,difficulty in early diagnosis,and often accompanies by different degrees of brain dysfunction.Early intervention is required to effectively restore deficits such as attention and memory.The above-mentioned dysfunctions are closely related to the functional abnormalities of the default network,hippocampus,basal ganglia and other brain areas,and imaging can accurately quantitatively evaluate the changes in these brain functional areas,especially the emergence of high-field magnetic resonance imaging technology,which has become a key technology for early clinical diagnosis and clinical treatment evaluation of mTBI.Based on mTBI animal models and clinical patients,this paper analyzes arterial spin labeling(ASL)reflecting working memory in magnetic resonance imaging(MRI),diffusion tensor imaging(DTI)for cognitive deficits,and ultra-high-field magnetic resonance imaging for abnormal lymphatic transport.Resonance-enhanced imaging,as well as positron emission computed tomography(PET)and electroencephalography(EEG)studies that reflect the degree of traumatic brain injury are reviewed,which may provide references for military medical research of mTBI.
关键词
多模态影像学/轻度创伤性脑损伤/磁共振成像/mTBI动物模型/脑功能成像Key words
multimodal imaging/mild traumatic brain injury/magnetic resonance imaging/mTBI animal model/functional brain imaging引用本文复制引用
基金项目
国家自然科学基金面上项目(81971603)
出版年
2024
国家科技期刊平台
NSTL
万方数据