黑色素纳米颗粒在M1/M2巨噬细胞极化中的作用研究进展
Research advances in melanin nanoparticles in M1/M2 macrophage polarization
黄萌 1刘伟 2张鲁岳 1张敏 1王朝祥 1丁祝雯 3曹均凯3
作者信息
- 1. 解放军医学院,北京 100853;解放军总医院第一医学中心老年口腔科,北京 100853
- 2. 军事科学院军事医学研究院军事认知与脑科学研究所,北京 100850
- 3. 解放军总医院第一医学中心老年口腔科,北京 100853
- 折叠
摘要
纳米材料具有尺寸小、易被吞噬的特性,其在细胞免疫调控与组织再生领域的作用成为研究热点.黑色素纳米颗粒因来源广泛和性能良好而备受关注.本文综述了黑色素纳米颗粒在调控M1/M2巨噬细胞极化转变方面的研究进展,探讨了黑色素纳米颗粒对M1型和M2型巨噬细胞极化的影响,分析可能的调控机制,并对其临床应用前景进行展望.
Abstract
In recent years,researchers on nanomaterials in the fields of cell regulation and tissue regeneration have gradually deepened due to their small size and susceptibility to phagocytosis.Among them,melanin nanoparticles have drawn much attention due to their wide range of sources and good performance.The progression of melanin nanoparticles in regulating macrophage phenotype is reviewed,the effects of melanin nanoparticles on M1 and M2 macrophages and the possible regulatory mechanisms are discussed and analyzed,and then the prospects for clinical application are prospected in this article.
关键词
纳米颗粒/巨噬细胞/免疫调控/纳米材料/组织再生Key words
nanoparticles/macrophage/immunomodulation/nanomaterials/tissue regeneration引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据