口腔类器官的构建及应用进展
Research advances in construction and application progress of oral organoids
孙红春 1李亚男 1刘璟珑 2杨烁 3时权3
作者信息
- 1. 海军第 971 医院卫勤处,山东青岛 266071
- 2. 解放军总医院京中医疗区口腔科,北京 100120
- 3. 解放军总医院第一医学中心口腔科,北京 100853
- 折叠
摘要
口腔是人体的重要组成部分,在维持机体稳态和健康方面发挥着重要作用.类器官作为干细胞衍生的复杂 3D细胞簇,能够模拟真实口腔器官的结构和功能,已广泛应用于口腔器官发育、疾病模型和再生医学的研究.本文主要就口腔类器官的构建系统和应用现状进行综述,同时讨论了口腔类器官技术面临的挑战和未来发展方向,旨在为口腔类器官的研发和应用提供新思路.
Abstract
The oral cavity is an essential part of the human body,playing a significant role in maintaining homeostasis and health.Organoids,as complex 3D clusters derived from stem cells,can simulate the structure and function of real oral organs and have been widely used in the study of oral organ development,disease modeling,and regenerative medicine.This article primarily reviews the construction systems and current application status of oral organoids,discusses the challenges and future directions of oral organoid technology,aiming to provide new ideas for the research and application of oral organoids.
关键词
口腔/类器官/干细胞/疾病模型/再生医学Key words
oral cavity/organoid/stem cell/disease model/regenerative medicine引用本文复制引用
出版年
2024
国家科技期刊平台
NSTL
万方数据