化妆品中16α-羟基泼尼松龙含量的不确定度评定
Uncertainty evaluation for determination of 16alpha-hydroxyprednisolone in cosmetics
刘齐 1郭洁 1王琪 1张华珺1
作者信息
- 1. 北京市药品检验研究院 北京 102206
- 折叠
摘要
参考国家药品监督管理局关于发布《化妆品中16α-羟基泼尼松龙的测定》化妆品补充检验方法的公告(2022年第107号)中《化妆品中16α-羟基泼尼松龙的测定(BJH 202203)》对化妆品中16α-羟基泼尼松龙进行测定.同时依据JJF 1059.1-2012《测量不确定度评定与表示》标准,建立测定16α-羟基泼尼松龙的不确定度数学模型,并对不确定度的来源进行评定.结果显示,当化妆品中16α-羟基泼尼松龙含量为0.105 6mg/kg时,扩展不确定度为0.008 1 mg/kg(k=2,置信概率95％).不确定度的主要来源为标准曲线拟合及样品测量重复性.
Abstract
According to the supplementary determination method of 16alpha-hydroxyprednisolone in announcement by SDA(No.107 of 2022),the 16alpha-hydroxyprednisolone in cosmetics was detected.In accordance with JJF 1059.1-2012 Evalua-tion and Expression of Uncertainty in Measurement,a mathematical model for the determination of 16alpha-hydroxypred-nisolone was established and each source and uncertainty component were analyzed and evaluated.The results showed that the content of 16alpha-hydroxyprednisolone in cosmetics was 0.105 6 mg/kg and the relative expanded uncertainty of mea-surement result was 0.008 1 mg/kg(k=2,confiidence level 95％).The uncertainty mainly caused by calibration fitting and measurement repeating.
关键词
计量学/三重四极杆质谱法/化妆品/16α-羟基泼尼松龙/不确定度Key words
Metrology/Triple quadrupole mass spectrometry/Cosmetics/16alpha-hydroxyprednisolone/Uncertainty引用本文复制引用
出版年
2024
NETL
NSTL
万方数据