Objective To investigate the effects of repetitive transcranial magnetic stimulation(rTMS)on core symptoms and brain functional connectivity in children with autism spectrum disorder(ASD).Methods Sixty-five ASD children were randomly divided into a control group and an observation group.The control group received conventional rehabilitation treatment,while the observation group underwent conventional rehabilitation combined with rTMS treatment.Before and after treatment,the autism behavior checklist(ABC)and childhood autism rating scale(CARS)were used to evaluate the core symptoms of ASD.Functional near-infrared spectroscopy(fNIRS)technology was used to detect changes in blood oxygen concentration in the prefrontal cortex,and resting-state functional connectivity(RSFC)of the region of interest(ROI)was analyzed.Results After treatment,the ABC and CARS scores of both groups significantly decreased compared to those before treatment(P<0.05),with the observation group showing a more significant decrease(P<0.05).The fNIRS testing revealed that the RSFC within and between the ROI of ASD children in the observation group was higher than that in the control group after treatment.Among them,there were significant differences in the RSFC within the left and right prefrontal cortex,as well as between the left and right prefrontal lobes and between the left temporal lobe and the left anterior and middle frontal lobes(P<0.05).Conclusion rTMS can effectively improve the core symptoms and brain functional connectivity of children with ASD.
关键词
孤独症谱系障碍/重复经颅磁刺激/功能性近红外光谱技术/脑功能连接
Key words
autism spectrum disorder/repetitive transcranial magnetic stimulation/functional near-infrared spectroscopy/brain functional connectivity
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