Objective To discuss the clinical effect of one-stage posterior approach on patients with skipped thoracolumbar brucel-losis spondylitis.Methods From September 2016 to October 2019,the clinical data of 12 patients with skipped thoracolumbar brucel-losis spondylitis were retrospectively analyzed.The visual analogue scales(VAS),the Japanese Orthopaedic Association Scores(JOA),the Oswestry disability index(ODI),the American spinal injury association(ASIA),erythrocyte sedimentation rate(ESR)and C-reactive protein(CRP)are used for clinical efficacy evaluation.Results Two weeks after operation and one year after opera-tion,VAS,JOA and ODI were significantly different from those before operation(all P<0.001).Moreover,VAS,JOA and ODI were statistically different at one year after operation compared with two weeks after operation(all P<0.001).Two weeks after operation,ESR and CRP decreased compared with those before operation,but there were no statistical differences compared with those before op-eration(P=0.430,P=0.395).However,one year after operation,ESR and CRP were statistically different from those before opera-tion and two weeks after operation(all P<0.001).The ASIA classification of 9 patients with spinal cord or nerve compression symp-toms before the operation was 1 case of grade B,2 cases of grade C,and 6 cases of grade D.One year after operation,there was 1 case of grade D and 8 cases of grade E.There was statistical difference(P =0.011).Conclusion The one-stage posterior approach for the treatment of skipped thoracolumbar brucellosis spondylitis is safe and feasible.