Objective To evaluate the effect of paravertebral muscle fatty infiltration on unilateral biportal endoscopic treatment for lumbar degenerative diseases.Methods Eighty-nine consecutive patients with lumbar degenerative diseases were treated by unilateral biportal endoscopy from January 2020 to june 2022.The patients were assigned into three groups(Group A,normal group,22 pa-tients,0%~10%fatty infiltration;Group B,mild,group,36 patients,10%~50%fatty infiltration;Group C,severe group,31 pa-tients,>50%fatty infiltration);based on the paravertebral muscle fatty infiltration,the indicators of perioperative period,VAS score,ODI index,and surgical complications were compared among the three groups.Results The patients in all three groups successfully completed the operation and were followed up.In terms of operation time,hospitalization time and complication rate,no significant sta-tistic difference was detected among the groups(P>0.05).The ODI index and VAS score were both improved significantly one month/three months after operation(P<0.05),as compared to the basal line values;however,the VAS score of low back pain three days after operation in group C was significantly higher than that in group A and group B(P<0.05).The VAS score of low back pain and ODI index 1 month after operation in group C were significantly higher than those in group A and B(P<0.05).There was no sig-nificant difference in VAS score and ODI index three months after operation among the groups(P>0.05).The results of Fischgrund evaluation criteria three months after operation showed that 39 cases were excellent,39 cases were good,11 cases were fair,and the excellent and good rate was 87.6%.There was no significant difference among the three groups(P>0.05).Conclusion Unilateral biportal endoscopic decompression for lumbar degenerative patients with severe paravertebral muscle fatty infiltration has relatively slow recovery of low back pain symptoms and lumbar function,but has no significant effect on the overall efficacy.