Objective To explore the clinical efficacy of ultrasound and digital subtraction angiography(DSA)-guided block in the treatment of cervical spondylotic radiculopathy(CSR).Methods A total of 88 CSR patients in our hospital from February 2020 to February 2022 were selected as the study subjects,and all of them were treated with cervical spinal nerve root block.They were divid-ed into two groups according to different puncture guidance methods,46 cases were guided by ultrasound,which was set as the ultra-sound group,and 42 cases were guided by DSA,which was set as the DSA group.The success rate of one puncture,puncture time and operation time were compared between the two groups.The postoperative adverse reactions were recorded.The pain visual analog scale(VAS)and neck disability index(NDI)were compared before surgery,on the day after surgery,and one month after surgery.Results The success rate of one puncture in the ultrasound group was higher than that in the control group,and the puncture time and opera-tion time were shorter than those in the control group(P<0.05).The total incidence of adverse reactions in the ultrasound group was significantly lower than that in the control group(P<0.05).The VAS and NDI in the two groups on the day after surgery and one month after surgery were significantly lower than those before surgery(P<0.05).There was no significant difference between the groups(P>0.05).Conclusion Both ultrasound and DSA-guided block therapy for CSR can achieve good short-term efficacy,but compared with DSA-guided,ultrasound-guided puncture is more efficient and has a lower incidence of related adverse reactions.