Objective To evaluate the clinical efficacy of percutaneous foraminal endoscopy in the treatment of adjacent segment disc herniation after lumbar spine fixation surgery.Method From March 2014 to July 2019,26 patients with adjacent segment interver-tebral disc herniation after lumbar spine fixation surgery were treated with percutaneous foraminal endoscopy,including 18 males and 8 females;The age range was 21-72 years,and this surgery was 3-15 years after lumbar spine fixation surgery.Surgical segments:L3-4 3 cases,L4-5 12 cases,L5-S1 11 cases;All patients were treated with percutaneous foraminal endoscopy.VAS scores were per-formed immediately,1 day,1 month,3 months,and 2 years after surgery.Lumbar function was evaluated using the Oswestry Dysfunc-tion Index 2 months after surgery,and the efficacy was evaluated using the modified MacNab standard.Result 26 patients were fol-lowed up for 24-36 months.The patients'postoperative symptoms were significantly improved compared to preoperative,with reduced back pain and lower limb pain.The VAS scores immediately,1 day,1 month,3 months,and 2 years after surgery were significantly lower than preoperative(P<0.01),and the ODI index at 2 years after surgery was significantly lower than preoperative(P<0.05).At the last follow-up,the modified MacNab scoring system was used to evaluate the surgical efficacy;excellent in 21 cases,good in 4 cases,and fair in 1 case,with an excellent and good rate of 96%.Conclusion Percutaneous foraminal endoscopy technique for the treatment of adjacent segment intervertebral disc herniation after lumbar spine fixation surgery has minimal structural damage to spinal stability,thorough decompression,rapid postoperative recovery,and satisfactory therapeutic effect.