摘要
目的 探讨肌肉减少性肥胖与骨质疏松性椎体骨折的关系.方法 选择2018年1月至2021年12月在该院就诊的骨质疏松性椎体骨折(OVF)患者121例作为研究组,按照1∶2比例抽取同期在该院就诊的骨质疏松症但未发生椎体骨折(ONVF)的患者242例作为对照组.观察两组患者的肥胖状态及其他临床资料,采用多因素Logisitc回归模型分析肌肉减少性肥胖、内脏肥胖、肌肉力量等与OVF的关系.结果 研究组肌肉减少性肥胖患者比例显著高于对照组,差异有统计学意义(P＜0.05).研究组患者年龄、吸烟、共病数量、腹围(WC)、体脂率、内脏脂肪含量(FMA)、皮下脂肪含量(FMG)、FMA/FMG(A/G)、躯干脂肪均低于对照组患者(P＜0.05),研究组患者四肢骨骼肌质量(ASM)、骨骼肌指数(SMI)、骨密度(BMD)和握力(HGS)均显著低于对照组(P＜0.05).多因素分析显示,肌肉减少性肥胖不是OVF的风险因素(P＞0.05),ASM、HGS是OVF的保护性因素(P＜0.05),A/G是OVF的风险因素.结论 BMI和ASM定义的肌肉减少性肥胖与OVF风险无独立相关性,但表示内脏脂肪水平的A/G、肌肉质量的ASM和肌肉力量与OVF独立相关.
Abstract
Objective To investigate the relationship between sarcopenic obesity and osteoporotic vertebral fracture.Methods 121 patients with osteoporotic vertebral fracture who were treated in our hospital from January 2018 to December 2021 were selected as the study group,and 242 patients with osteoporotic non vertebral fracture who were treated in our hospital in the same period were se-lected as the control group according to the ratio of 1∶2.The obesity status and other clinical data of the two groups were observed,and the relationship between muscle reducing obesity,visceral obesity,muscle strength and OVF was analyzed by multifactor logisitc.Results The proportion of patients with sarcopenic obesity in the study group was significantly higher than that in the control group(P＜0.05).The age,smoking,number of comorbidities,waist circumference(WC),body fat rate,and roid fat mass(FMA),gynoid fat mass(FMG),FMA/FMG(A/G)and trunk fat of the study group were lower than those of the control group(P＜0.05),and the limb skeletal muscle mass(ASM),skeletal muscle index(SMI),bone mineral density(BMD)and grip strength(HGS)in the study group were lower than those in the control group(P＜0.05).Multivariate analysis showed that sarcopenic obesity was not a risk factor for OVF(P＞0.05),ASM and HgS were protective factors for OVF(P＜0.05),and a/g was a risk factor for OVF(P＜0.05).Conclusion Sarcopenic obesity defined by BMI and ASM has no independent correlation with OVF risk,but the A/G of visceral fat level,ASM of muscle mass and muscle strength are independently correlated with OVF.
维普
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