Objective To investigate the predictive value of the serum calcium-phosphorus product for osteoporotic vertebral com-pression fractures in elderly individuals.Methods A retrospective analysis was conducted on 100 patients admitted for vertebroplasty due to OVCF in elderly individuals between July 2018 and June 2022,constituting the observation group.An equivalent number of age-and gender-matched patients undergoing surgical treatment for spinal degenerative diseases during the same period were selected as the control group.General demographic and laboratory data at the time of admission were compared between the two groups.Logistic re-gression was employed to analyze factors associated with the occurrence of OVCF in the elderly.Receiver Operating Characteristic curves were plotted to evaluate the effectiveness of these factors in assessing the risk of OVCF in elderly patients,and the results were compared to those of the Osteoporosis Self-Assessment Tool for Asians,a tool designed to assess OVCF risk in elderly patients of Asian descent.Results The observation group exhibited statistically significant lower levels of albumin,serum calcium,phosphorus,calci-um-phosphorus product,corrected blood calcium,corrected calcium-phosphorus product,and OSTA index compared to the control group(P<0.05).Logistic regression analysis indicated that higher serum calcium,phosphorus,calcium-phosphorus product,correc-ted blood calcium,corrected calcium-phosphorus product,and OSTA index were protective factors against OVCF in the elderly.ROC curve results demonstrated that the Area Under the Curve values for serum calcium-phosphorus product,corrected calcium-phosphorus product,and OSTA in diagnosing OVCF in the elderly were 0.810,0.772,and 0.659,respectively.Notably,the predictive capabili-ties of the serum calcium-phosphorus product and corrected calcium-phosphorus product were superior to those of the OSTA index.Conclusion Serum calcium-phosphorus product and corrected calcium-phosphorus product hold predictive value for the occurrence of OVCF in the elderly population.