Objective To explore the clinical application of hybrid reality technology in minimally invasive intervertebral foramen puncture and blind puncture.Methods 74 patients with lumbar disc herniation who were treated with percutaneous transforaminal en-doscopic discectomy(PTED)in our hospital from July 2019 to June 2021 were selected as the research objects.The patients were ran-domly divided into control group and study group,with 37 cases in each group.The control group used traditional C-arm X-ray ma-chine to puncture the intervertebral foramen,and the study group used mixed reality guidance.The times of intraoperative puncture,fluoroscopy,operation time and postoperative complications were observed.The VAS scores of patients in the two groups were recorded before operation,1 day after operation,3 months after operation and 6 months after operation.Results The puncture time,fluorosco-py time and operation time in the study group were significantly lower than those in the control group(P<0.05).There was no signifi-cant difference in VAS scores between the two groups before operation,1 day after operation,3 months after operation and 6 months af-ter operation(P>0.05).The incidence of complications in the study group was significantly lower than that in the control group(P<0.05).Conclusion The hybrid reality technique can increase the puncture accuracy of PTED,reduce the number of repeated punc-ture and radiation exposure time,and reduce postoperative complications.It has clinical significance.