Objective To compare and analyze the clinical efficacy of unilateral biportal endoscopy(UBE)and percutaneous en-doscopic lumbar discectomy(PELD)in the treatment of degenerative lumbar spinal stenosis(LSS).Methods Seventy-three LSS pa-tients admitted to our hospital from May 2019 to May 2021 were treated with spinal endoscopic decompression.They were divided into two groups according to different surgical schemes:the UBE group was treated with UBE decompression(42 cases),and PELD group with PELD decompression(31 cases).The perioperative conditions,postoperative efficacy and spinal canal decompression of the two groups were compared and analyzed.Results All patients in the two groups successfully completed spinal endoscopic decompression,and there was no significant difference in the postoperative hospital stay and complication rate between the two groups(P>0.05).The operation time in the UBE group was significantly shorter than that in the PELD group(P<0.05).In the UBE group,one patient had symptoms of nerve root irritation after operation;there were two cases of nerve root irritation symptoms in the PELD group after opera-tion,and the difference was not statistically significant(P>0.05).Compared with that before treatment,the VAS score and ODI in-dex of the two groups were significantly improved one month and one year after operation(P<0.05),but there was no significant difference between the two groups(P>0.05).The excellent and good rate was 92.9%in the UBE group and 90.3%in the PELD group one year after operation,with no significant difference(P>0.05).The cross sectional area of the dural sac after operation in both groups significantly increased compared with that before operation(P<0.05),and the cross sectional area of the dural sac after operation in the UBE group was significantly greater than that in the PELD group(P<0.05).Conclusion Both PELD and UBE are safe and effective endoscopic decompression for LSS.But UBE surgical decompression is more thorough,and the clinic can choose flexibly according to the actual condition of patients.