Objective To investigate the correlation between vertebral height loss rate and adjacent vertebral fracture(AVF)in patients with osteoporotic vertebral compression fracture(OVCF)after PKP.Methods The medical records of 147 patients with OVCF treated with PKP in our hospital from January 2019 to December 2021 were retrospectively analyzed.According to whether AVF occurred,the patients were divided into group A(AVF group,28 case)and group B(non AVF group,119 case).The rate of vertebral body height loss(This paper adopted two methods to calculate the vertebral body height loss rate,namely VBHL1 and VBHL2)in the two groups was observed,and the relationship between VBHL1 and VBHL2 and AVF after removing confounding factors.Results VBHL1 and VBHL2 in group A were significantly higher than those in group B(P<0.05).After operation,VBHL1 and VBHL2 in group A were significantly higher than those in group B,and the changes of VBHL1 and VBHL2 before and after operation were signifi-cantly higher than those in group B(P<0.05).Multivariate logistic analysis showed that VBHL1 ≥61.3%or VBHL2≥62.1%were the risk factors of AVF(P<0.05).Spearman correlation showed that vbhl1 was positively correlated with bone cement volume,local kyphosis angle,wedge angle and VBHL1 change(r=0.308,0.605,0.572 and 0.588,all P<0.05),and VBHL2 was positively correlated with bone cement volume,local kyphosis angle,wedge angle and vbhl1 change(r=0.337,0.677,0.593 and 0.601,all P<0.05).Conclusion The incidence of PKP after PKP in OVCF patients is higher,which is significantly correlated with the loss rate of vertebral body height,and targeted prevention and intervention should be carried out in clinical practice.