Objective To observe the effect of remazolam and propofol on agitation in elderly patients undergoing spinal surgery during recovery from general anesthesia.Methods Eighty elderly patients who underwent spinal surgery from July 2022 to July 2023 were randomly divided into two groups,40 cases in the remimazolam group and 40 cases in the propofol group.In the remimazolam group,0.2-0.4 mg/kg of remimazolam was administered intravenously for induction,and anesthesia was maintained at a rate of 0.3～0.5 mg/kg/h;propofol group was induced by intravenous injection of 1.5～2 mg/kg propofol,and maintained anesthesia at the rate of 4～8mg/kg/h.Intraoperative hemodynamics,agitation during recovery from general anesthesia,adverse events during post anesthe-sia intensive care unit(PACU)and postoperative clinical data were compared between the two groups.Results At 1 min after induc-tion and 5 min after insertion of laryngeal mask airway,the heart rate and mean arterial pressure in the remimazolam group were higher than those in the propofol group at the beginning of operation(P＜0.05).The SAS score,emergence agitation rate and duration of agi-tation in the remimazolam group were lower than those in the propofol group(P＜0.05).There were 1 case of hypoxemia and 2 cases of hypotension in the remimazolam group,1 case of nausea and vomiting in the propofol group,1 case of venous access removal,4 ca-ses of hypoxemia and 5 cases of hypotension in the remimazolam group.The incidence of adverse events during PACU in remimazolam group was lower than that in propofol group.Conclusions Remazolam can reduce the incidence of agitation in elderly patients with spinal surgery during recovery from general anesthesia.In addition,the use of remazolam has little impact on hemodynamics,and the incidence of adverse events during PACU is low.
关键词
瑞马唑仑/丙泊酚/苏醒期躁动/老年患者/脊柱手术
Key words
remazolam/propofol/emergence agitation/elderly patients/spinal surgery
维普
万方数据