Effect of warming yang and nourishing marrow formula combined with platelet-rich plasma on the levels of serum S100B and CTX-Ⅱ in the treatment of early and middle stage knee osteoarthritis
Objective To analyze the therapeutic effect of warming yang and nourishing marrow formula com-bined with platelet rich plasma(PRP)in the treatment of early and middle stage knee osteoarthritis(KOA)and its effect on serum S100B and C-terminal peptide of type Ⅱ collagen(CTX-Ⅱ)levels.Methods A total of 150 patients with early and middle KOA admitted to this hospital from April 2021 to January 2023 were selected as the study objects and were divided into the observation group and the control group according to random number table method,with 75 patients in each group.The clinical efficacy,incidence of total adverse reactions,recur-rence rate,Lysholm Knee Function Scale(LKS)score and serum S100B,CTX-Ⅱ levels before treatment and 1 month after treatment,as well as Visual Analog Scale(VAS)score before treatment,1 week after treatment and 1 month after treatment were compared between the two groups.Results The total effective rate of the observation group was higher than that of the control group,and the recurrence rate of the observation group was lower than that of the control group,with statistical significance(P＜0.05).After 1 month of treatment,the LKS score of the two groups was higher than that before treatment,and the LKS score of the observation group was higher than that of the control group,with statistical significance(P＜0.05).Repeated measures a-nalysis of variance showed that there was an interaction effect between the changes of VAS scores during the treatment in the two groups(F=20.132,P=0.030),so further separate effect analysis was performed.VAS scores of the control group and the observation group after 1 week and 1 month of treatment were lower than before treatment,and VAS scores of 1 month after treatment were lower than after 1 week of treatment,and the differences were statistically significant(P＜0.05).After 1 month of treatment,serum S100B and CTX-Ⅱlevels in two groups were lower than before treatment,and the observation group was lower than the control group,the differences were statistically significant(P＜0.05).There was no significant difference in the total adverse reaction rate between the two groups(P＞0.05).Conclusion Warming yang and nourishing marrow formula combined with PRP can effectively relieve pain symptoms,improve serum S100B and CTX-Ⅱ levels,promote functional rehabilitation of knee joint and reduce the recurrence rate of the disease,which is worthy of clinical promotion.
knee osteoarthritiswarming yang and nourishing marrow formulaplatelet rich plasmaS100BC-terminal peptide of type Ⅱ collagen
万方数据
维普
