Effects of Wenshen Huatan decoction combined with Western medicine on sex hormone,glucose metabolism,ovulation rate and pregnancy rate,efficacy and adverse reactions in patients with kidney deficiency phlegm-dampness PCOS and IR infertility
Objective To analyze the effects of Wenshen Huatan decoction combined with Western medi-cine on sex hormone,glucose metabolism,ovulation rate,pregnancy rate,efficacy and adverse reactions in pa-tients with polycystic ovary syndrome(PCOS)and insulin resistance(IR)infertility.Methods A total of 61 kidney deficiency phlegm-dampness PCOS with IR infertility patients admitted to the Department of Repro-ductive Medicine of Henan Provincial Hospital of Traditional Chinese Medicine from December 2022 to July 2023 were selected as the study objects and randomly divided into the experimental group(31 cases)and the control group(30 cases).The control group was treated with metformin hydrochloride tablets and letrozole tablets,and the experimental group was treated with Wenshen Huatan decoction on the basis of this treat-ment.Both groups were given 3 menstrual cycles.Serum testosterone(T),luteinizing hormone(LH),follicle stimulating hormone(FSH)levels,LH/FSH ratio,body mass index(BMI),fasting blood glucose(FBG),fasting insulin(FINS),homeostasis index model(HOMA-IR),ovulation rate,pregnancy rate and efficacy of patients were observed before and after treatment,and security assessment was carried out.Results Before treatment,there were no significant differences in BMI,HOMA-IR,LH/FSH ratio and serum T,LH,FSH,FBG,FINS levels between the two groups(P＞0.05).After treatment,BMI,HOMA-IR,LH/FSH ratio and serum T,LH,FBG and FINS levels in two groups were lower than before treatment,serum FSH level was higher than before treatment,and BMI,HOMA-IR,LH/FSH ratio and serum T,LH,FBG,FINS levels in the experimental group were lower than those in the control group,and serum FSH level in the experimental group was higher than those of the control group,and the differences were statistically significant(P＜0.05).The total effective rate,ovulation rate and pregnancy rate of experimental group were higher than those of the control group,and the incidence of total adverse reactions was lower than that of the control group,with sta-tistical significances(P＜0.05).Conclusion The efficacy of Wenshen Huatan decoction combined with con-ventional Western medicine in treating infertility associated with kidney deficie-ncy and phlegm-dampness pat-tern of PCOS with IR is superior to conventional Western medicine alone,which can increase ovulation rate and pregnancy rate,improve female sex hormone,glucose metabolism index levels,alleviate IR,improve clini-cal symptoms of traditional Chinese medicine,with good safety.
万方数据
维普
