Effects of hyperbaric oxygen combined with oxiracetam+citicoline on cognitive function,hemorheology,and serum Tau protein level in patients with carbon monoxide poisoning
Objective To analyze the effects of hyperbaric oxygen combined with olanzapine+cytarabine on cognitive function,haemodynamics and serum Tau protein level in patients with carbon monoxide poison-ing.Methods Ninety-four carbon monoxide poisoning patients who were treated in this hospital from June 2021 to October 2022 were selected as study subjects,and they were divided into the observation group and the control group according to the random number table method,with 47 cases in each group.The control group was treated with hyperbaric oxygen,and the observation group was treated with olaxetan+cytarabine on the basis of the control group.The efficacy of the two groups and the Montreal Cognitive Assessment Scale(Mo-CA)score,the Brief Mental State Evaluation Scale(MMSE)score,the Barthel Index(BI),plasma viscosity,platelet aggregation rate,whole blood low-cut viscosity,whole blood high-cut viscosity and serum Tau protein level before and after treatment were compared.Results The total effective rate in the observation group was higher than that in the control group(P＜0.05).The MoCA,MMSE score and BI in two groups after treat-ment were higher than before treatment,and those in the observation group were higher than those in the con-trol group,and the differences were statistically significant(P＜0.05).Plasma viscosity,platelet aggregation rate,whole blood low-cut viscosity and whole blood high-cut viscosity were lower than before treatment in two groups after treatment,and those in the observation group were lower than those in the control group,and the differences were statistically significant(P＜0.05).The Tau protein level of two groups after treatment was lower than that before treatment,and that in the observation group was lower than that in the control group,and the differences were statistically significant(P＜0.05).Conclusion Hyperbaric oxygen combined with oxiracetam+citicoline is effective in the treatment of patients with carbon monoxide poisoning,which can ef-fectively improve the patients'cognitive function and hemorheological indicators and reduce the level of serum Tau protein.
hyperbaric oxygenoxiracetamciticolinecarbon monoxide poisoningcognitive func-tionhemorheologyTau protein
万方数据
维普
