Effect of self-designed Wenjing Tongluo decoction combined with acupuncture on cerebral perfusion status and serum MFG-E8 level in patients with vertigo after stroke
Objective To analyze the effects of self-designed Wenjing Tongluo decoction combined with ac-upuncture on cerebral perfusion status and serum milk fat globule epidermal growth factor-8(MFG-E8)level in patients with vertigo after stroke.Methods A total of 80 patients with vertigo after stroke admitted to this hospital from August 2018 to August 2020 were selected as the study objects and were divided into control group and treatment group according to random number table method,with 40 cases in each group.The con-trol group was treated with conventional Western medicine,and the treatment group was treated with self-de-signed Wenjing Tongluo decoction combined with acupuncture on the basis of the control group.The efficacy of the two groups and the scores of traditional Chinese medicine(TCM)symptoms scores,mean blood flow velocity in each cerebral artery and serological indexes before and after treatment were compared,and the inci-dence of adverse reactions between the two groups during treatment was counted.Results The total effective rate of the treatment group was higher than that of the control group(P＜0.05).After 2 weeks of treatment,serum soluble CD40 ligand(sCD40L),MFG-E8,lipoprotein-associated phospholipase A2(Lp-PLA2)levels and TCM syndrome scores in two groups were lower than before treatment,and which in the treatment group were lower than those in the control group,with statistical significance(P＜0.05).After 2 weeks of treat-ment,the mean blood flow velocity of the basal basilar artery,left and right vertebral arteries in two groups were higher than before treatment,and which in the treatment group were higher than those in the control group,with statistical significance(P＜0.05).No serious adverse reactions occurred in two groups during treatment.Conclusion On the basis of acupuncture treatment of patients with vertigo after stroke,the com-bined treatment of self-designed Wenjing Tongluo decoction has a significant effect,which can significantly improve the clinical symptoms and brain perfusion state and regulate the level of serum MFG-E8.
万方数据
维普
