Analysis of risk factors of embryo termination in early pregnancy and construction of nomogram diagnostic model
Objective To analyze the risk factors of embryo termination in early pregnancy,and construct a nomogram diagnostic model for verification.Methods Seventy-two patients with early pregnancy embryo ter-mination admitted to the hospital from June 2020 to July 2022 were retrospectively selected and included in the sterility group,and 158 healthy pregnant women who underwent birth examination in the hospital during the same period were selected as the control group.The clinical data of the two groups were compared,and the influencing factors of embryo termination in early pregnancy were analyzed by multivariate Logistic regres-sion.The diagnostic model of the risk of embryo termination in early pregnancy was constructed,and the diag-nostic efficiency of the model was verified by receiver operating characteristics(ROC)curve and calibration curve.Results The age in the sterility group was older than that in the control group,and the proportions of patients with thyroid disease,abnormal uterus,abnormal semen level of male partners,poor metabolism of fo-lic acid and exposure to radioactive substances in the sterility group were higher than those in the control group,and the differences were statistically significant(P＜0.05).Multivariate Logistic regression analysis showed that older age,thyroid disease,abnormal uterus,abnormal semen level of male partners,poor folate metabolism and exposure to radioactive substances were risk factors for embryo termination in early pregnan-cy(P＜0.05).The nomogram diagnostic model was internally verified by Bootstrap self-sampling,and the consistency index was 0.719.ROC curve analysis showed that the area under the curve of the model for diag-nosing embryo arrest in early pregnancy was 0.813.Conclusion Older age,thyroid disease,abnormal uterus,abnormal semen level of male partner,poor metabolism of folic acid and exposure to radioactive substances are the independent risk factors for embryo termination in early pregnancy.Medical examination and related inter-vention measures for women of childbearing age have a positive effect on risk factors,and the nomogram mod-el based on each risk factor has high clinical application value.Doctors can quickly and accurately assess the risk of embryo loss in early pregnancy,so as to provide better diagnosis and treatment options for patients.
early pregnancyembryo terminationnormal development of pregnancyrisk factornomogram
万方数据
维普
