Application value of combined detection of inflammatory factors in patients with gestational diabetes mellitus
Objective To analyze the application value of the combined detection of inflammatory factors in patients with gestational diabetes mellitus(GDM).Methods A total of 98 GDM patients treated at the First Affiliated Hospital of Xiamen University from January 2022 to April 2024 were selected as the observation group,and 40 healthy pregnant women who underwent prenatal examination in the First Affiliated Hospital of Xiamen University during the same period were selected as the control group.The white blood cell count(WBC),procalcitonin(PCT),interleukins-6(IL-6)and C-reactive protein(CRP)levels were detected.Based on the results of the oral glucose tolerance test the severity of GDM was graded,and according to whether ad-verse pregnancy outcome occurred,GDM patients were divided into the poor pregnancy outcome group and the good pregnancy outcome group.Receiver characteristic(ROC)curve was drawn to analyze the predictive value of inflammatory factors for poor pregnancy outcomes in GDM patients.Results The WBC,PCT,IL-6 and CRP levels of the observation group were higher than those of the control group,and the differences were sta-tistically significant(P＜0.05).There were 58,25 and 15 cases of mild,moderate and severe GDM patients respectively.The levels of WBC,PCT,IL-6 and CRP in GDM patients with different severity were compared,with mild patients＜moderate patients＜severe patients,and any pairings had statistical significance(P＜0.05).The total incidence of adverse pregnancy outcomes in the observation group was higher than that in the control group,and the difference was statistically significant(P＜0.05).There were 46 patients in the good pregnancy outcome group and 52 patients in the poor pregnancy outcome group.The levels of WBC,PCT,IL-6 and CRP in the poor pregnancy outcome group were higher than those in the good pregnancy outcome group,and the differences were statistically significant(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of WBC,PCT,IL-6 and CRP to predict poor pregnancy outcomes in GDM pa-tients alone were 0.690,0.805,0.820 and 0.753 respectively,and the AUC of the combined detection of the 4 indicators was 0.947.Conclusion Levels of WBC,PCT,IL-6 and CRP are elevated in GDM patients,and these indicators can be used as predictors of poor pregnancy outcomes in GDM patients,which may be closely relat-ed to the diagnosis,development and prognosis of GDM.
gestational diabetes mellituspoor pregnancy outcomewhite blood cell countprocalci-tonininterleukin-6C-reactive protein
万方数据
维普
