Predictive value of serum SCUBE1,CLEC-2 and UCP2 for poor prognosis in patients with acute ischemic stroke after intravenous thrombolysis
Objective To analyze the predictive value of the serum signal peptide-cub epidermal growth factor domain-containing protein 1(SCUBE1),C-type lectin like receptor-2(CLEC-2)and uncoupling protein 2(UCP2)in patients with acute ischemic stroke(AIS)after intravenous thrombolysis(IVT).Methods A total of 116 AIS patients who received IVT treatment at this hospital from June 2022 to October 2023 were collected as the observation group,and 116 healthy individuals who underwent physical examinations in this hospital during the same period were regarded as the control group.According to the modified Rankin Scale(mRS)score,the patients were classified as the good prognosis group and the poor prognosis group.Enzyme linked immunosorbent assay was used to determine the levels of serum SCUBE1,CLEC-2 and UCP2.Multiva-riate Logistic regression was used to analyze the influencing factors of poor prognosis in AIS patients after IVT.Receiver operating characteristic(ROC)curve was applied to analyze the predictive value of serum SCUBE1,CLEC-2 and UCP2 for poor prognosis in AIS patients after IVT.Results The serum levels of SCUBE1 and CLEC-2 in the observation group were higher than those in the control group,and the serum lev-el of UCP2 in the observation group was lower than that in control group,with statistical significance(P＜0.05).There were 75 patients in the good prognosis group and 41 patients in the poor prognosis group.The proportion of infarct area＞4 cm3,serum levels of SCUBE1 and CLEC-2 in the poor prognosis group were higher than those in the good prognosis group,and serum level of UCP2 in the poor prognosis group was low-er than that in the good prognosis group,with statistical significance(P＜0.05).Multivariate Logistic regres-sion analysis showed that the increase of serum SCUBE1 and CLEC-2 levels was a risk factor for poor progno-sis in AIS patients after IVT(P＜0.05),and the increase of serum UCP2 level was a protective factor for poor prognosis in AIS patients after IVT(P＜0.05).ROC curve analysis results showed that the area under the curve(AUC)of serum SCUBE1,CLEC-2 and UCP2 independently predicted the poor prognosis of AIS patients after IVT was 0.752,0.694 and 0.776 respectively,and the AUC of the combined prediction of the 3 inde-xes was 0.861.The AUC predicted by the 3 indexes combined was greater than that predicted by SCUBE1,CLEC-2 and UCP2 alone(Z3 combination-SCUBE1=2.358,Z3 combination-CLEC-2=2.714,Z3 combination-UCP2=2.591;P=0.018,0.007,0.010).Conclusion The levels of SCUBE1 and CLEC-2 are increased,and UCP2 is decreased in AIS patients with poor prognosis after IVT.The combined detection of the 3 indexes have a high predictive value for the poor prognosis of AIS patients after IVT.
signal peptide-cub epidermal growth factor domain-containing protein 1C-type lectin like receptor-2uncoupling protein 2acute ischemic strokeintravenous thrombolysisprognosis
万方数据
维普
