Objective To analyze the predictive value of cytoskeletal-associated protein 4(CKAP4)and complement C1q tumour necrosis factor related protein 9(CTRP9)on vascular calcification in maintenance hemodialysis(MHD)patients.Methods A total of 132 MHD patients admitted to the hospital from April 2021 to June 2023 were selected as the research subjects,and they were divided into the calcification group and the non-calcification group according to the total vascular calcification score,and 62 healthy people who under-went physical examination in the hospital during the same period were selected as the control group.The gen-eral data and serum CKAP4 and CTRP9 levels of the calcification group and the non-calcification group and the control group were compared,and the clinical data of the calcification group and the non-calcification group were compared.Pearson correlation was used to analyze the correlation between serum CKAP4,CTRP9 levels and related indexes of calcium and phosphorus metabolism in MHD patients.Multivariate Logistic regression was used to analyze the influencing factors of vascular calcification in MHD patients.Receiver operating char-acteristic(ROC)curve was drawn to analyze the predictive value of vascular calcification in MHD patients.Results Serum CKAP4 and CTRP9 levels in the non-calcification group and the calcification group were low-er than those in the control group,and those in the calcification group were lower than those in the non-calcifi-cation group,and the differences were statistically significant(P＜0.05).The levels of calcium,phosphorus and parathyroid hormone(PTH)in the calcification group were higher than those in the non-calcification group,and the differences were statistically significant(P＜0.05).Pearson correlation analysis showed that the serum levels of CKAP4 and CTRP9 were negatively correlated with the serum levels of calcium,phosphor-us and PTH in MHD patients(P＜0.05).Multivariate Logistic regression analysis showed that the decrease of serum CKAP4 and CTRP9 levels were risk factors for vascular calcification in MHD patients(P＜0.05).ROC curve analysis results showed that the area under the curve of serum CKAP4 and CTRP9 combined to predict the occurrence of vascular calcification was greater than that predicted by each indicator alone(Zcombined-CKAP4=2.307,P=0.021;Zcombined-CTRP9=2.484,P=0.013).Conclusion Serum CKAP4 and CTRP9 levels in MHD patients are significantly reduced,and the combined value of these two indexes is higher than that of single index in predicting the vascular calcium in MHD patients.
关键词
维持性血液透析/细胞骨架相关蛋白4/补体C1q肿瘤坏死因子相关蛋白9/血管钙化
Key words
maintenance hemodialysis/cytoskeleton-associated protein 4/complement C1q tumor nec-rosis factor related protein-9/vascular calcification
维普
万方数据