Clinical pathological features of lung cancer with non-tuberculous Mycobacterium infection
Objective To analyze the clinical pathological features,diagnosis and differential diagnosis of lung cancer with non-tuberculous Mycobacterium(NTM)infection to improve the understanding and diagno-sis level of tumor coinfection.Methods The clinical pathological features,immunophenotype and molecular biological characteristics of 16 patients of lung cancer with NTM infection in this hospital from January 2010 to December 2023 were retrospectively analyzed,and the literature was reviewed.Results The main clinical symptoms of 16 patients with lung cancer and NTM infection were fever,cough,sputum,hemoptysis and chest tightness,and only 1 patient had no clinical symptoms.Two patients had a history of smoking and 3 patients had underlying lung conditions such as multiple cystic bronchiectasis and lung cysts in both lungs.The histo-logical types of lung cancer were common squamous cell carcinoma in 5 cases,adenocarcinoma in 10 cases(in-cluding 5 cases of adenocarcinoma in situ or minimally invasive adenocarcinoma)and small cell carcinoma in 1 case.The results of Mycobacterium infection showed that 5 cases were infected with intracellular Mycobacteri-um,4 cases were infected with Mycobacterium chelonis/abscess,3 cases were infected with Mycobacterium avium,3 cases were infected with Mycobacterium bufo and 1 case was infected with Mycobacterium kansensis.The tumor stages were stage Ⅰ-Ⅱ in 12 cases and stage Ⅲ in 3 cases.After follow-up,one patient died of re-spiratory failure due to abandonment of tumor therapy.Conclusion Lung cancer complicated with NTM in-fection is a rare lung disease.In the course of diagnosis and treatment of lung cancer,repeated detection should be performed after the puncture of localized masses to diagnose the combination of NTM infection and lung cancer,especially for high-risk patients with diagnosed lung cancer,such as interstitial lung disease,bronchiec-tasis and neoadjuvant immune-related treatment.The presence of NTM infection needs to be further clarified.
万方数据
维普
