Diagnostic value of serum sTLT-1 and ESM-1 for transfusion related acute lung injury in ICU patients
Objective To evaluate the diagnostic value of serum soluble trem-like transcript-1(sTLT-1)and endothelial cell specific molecule-1(ESM-1)in transfusion related acute lung injury(TRALI)in intensive care unit(ICU)patients.Methods A total of 289 patients who underwent transfusion treatment in the ICU of this hospital from August 2021 to August 2023 were selected as the study objects,and they were divided in-to TRALI group(58 cases)and non-TRALI group(231 cases)according to whether they had TRALI.The serum levels of sTLT-1,ESM-1,interleukin(IL)-8,IL-6 and IL-1 were detected by enzyme-linked immu-nosorbent assay.Pearson correlation was used to analyze the correlation between serum sTLT-1 and ESM-1 levels and Lung Injury Prediction(LIPS)score,Sequential Organ Failure(SOFA)score,Acute Physiology and Chronic Health Status Ⅱ(APACHE Ⅱ)score and oxygenation index in patients of TRALI group.Receiv-er operating characteristic(ROC)curve was drawn to analyze the diagnostic value of serum sTLT-1 and ESM-1 in ICU patients with TRALI.Results The serum levels of sTLT-1,ESM-1,IL-8,IL-6 and IL-1 in TRALI group were higher than those in non-TRALI group,with statistical significance(P＜0.05).Pearson correla-tion analysis showed that serum sTLT-1 and ESM-1 levels were positively correlated with LIPS,SOFA and APACHE Ⅱ scores,and negatively correlated with oxygenation index in patients of TRALI group.ROC curve analysis results showed that the area under the curve(AUC)of TRALI in ICU patients diagnosed by sTLT-1 and ESM-1 alone were 0.852 and 0.809 respectively,and the AUC of TRALI in ICU patients diagnosed by two indicators combined was 0.934.The AUC of two indicators combined diagnosis of TRALI was signifi-cantly higher than that of sTLT-1 and ESM-1 alone diagnosis(Z=3.519 and 3.836,P＜0.001).Conclusion Be-fore TRALI in ICU patients,serum sTLT-1 and ESM-1 levels are elevated,which is closely related to the se-verity of lung injury in patients.The combined detection of sTLT-1 and ESM-1 is of high diagnostic value for TRALI in ICU patients.
soluble trem-like transcript-1endothelial cell specific molecule-1intensive care unittransfusion related acute lung injurydiagnostic value
万方数据
维普
