The diagnostic value of serum GGT,NGF and NfL for peripheral nerve related adverse reaction in colorectal cancer patients treated with oxaliplatin chemotherapy
Objective To evaluate the diagnostic value of serum γ-glutamyltransferase(GGT),nerve growth factor(NGF)and neurofilament light chain(NfL)levels for peripheral nerve related adverse reactions in colorectal cancer patients with oxaliplatin chemotherapy.Methods A total of 104 colorectal cancer patients who received oxaliplatin chemotherapy and experienced peripheral nerve related adverse reactions in this hos-pital from August 2021 to August 2023 were selected as the research group,and another 104 colorectal cancer patients who received oxaliplatin chemotherapy and did not experience peripheral nerve related adverse reac-tions in this hospital during the same period were selected as the control group.Spearman correlation was ap-plied to analyze the relationship between serum GGT,NGF,NfL levels and peripheral nerve adverse reaction ratings in colorectal cancer patients treated with oxaliplatin chemotherapy.Receiver operating characteristic curve(ROC)was plotted to analyze the diagnostic value of serum GGT,NGF and NfL for peripheral nerve re-lated adverse reactions in colorectal cancer patients with oxaliplatin chemotherapy.Results The levels of ser-um GGT and NfL in the research group were higher than those in the control group,while the level of NGF was lower than that in the control group(P＜0.05).In the research group,there were 23 cases of grade Ⅰ,38 cases of grade Ⅱ,29 cases of grade Ⅲ and 14 cases of grade Ⅳ peripheral nerve adverse reaction ratings.The comparison of serum GGT and NfL levels in patients with different peripheral nerve adverse reaction ratings showed that grade Ⅳ＞grade Ⅲ＞grade Ⅱ＞grade Ⅰ,and differences were statistically significant in any pair-wise comparison(P＜0.05).The comparison of serum NGF level in patients with different peripheral nerve adverse reaction ratings showed that grade Ⅳ＜grade Ⅲ＜grade Ⅱ＜grade Ⅰ,and differences were statistical-ly significant in any pairwise comparison(P＜0.05).Spearman correlation analysis showed that serum GGT and NfL in research group were positively correlated with peripheral nerve adverse reaction ratings(r=0.688 and 0.627,P＜0.05),and the level of NGF in research group was negatively correlated with the peripheral nerve adverse reaction ratings(r=-0.694,P＜0.05).ROC curve results showed that the area under the curve(AUC)of the combined diagnosis of the 3 indicators for peripheral nerve related adverse reactions in colorectal cancer patients with oxaliplatin chemotherapy was larger than the AUC of the individual diagnosis of GGT,NGF and NfL(Z=2.302,2.098,2.482,P＜0.05).Conclusion Serum GGT and NfL levels are obvi-ously increased and NGF level is obviously reduced in colorectal cancer patients who experience peripheral nerve related adverse reactions after oxaliplatin chemotherapy.The combination of 3 indicators has a high di-agnostic value for peripheral nerve related adverse reaction in colorectal cancer patients undergoing oxaliplatin chemotherapy and has certain clinical significance.
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