The therapeutic effects of the combination of Suxiao Jiuxin Pill and Xinhuosu on AMI patients after PCI based on vascular endothelial markers,IL-23 and IL-17
Objective To analyze the therapeutic effects of the combination of Suxiao Jiuxin Pill and Xinhu-osu on Acute Myocardial Infarction(AMI)patients after percutaneous coronary intervention(PCI)on based on vascular endothelial markers,interleukin-23(IL-23)and interleukin-17(IL-17).Methods A total of 104 patients with AMI admitted to this hospital from January 2021 to October 2022 were selected as the research subjects and were divided into control group and observation group according to random number table meth-od,with 52 cases in each group.Both groups underwent PCI.The control group was treated with Xinhuosu,and the observation group was treated with Xinhuosu+Suxiao Jiuxin Pill.The efficacy,adverse reactions,oc-currence of major adverse cardiovascular events(MACE),as well as Traditional Chinese Medicine(TCM)syn-drome scores,cardiac function indicators,vascular endothelial indicators and serum levels of IL-23 and IL-17 were compared between the two groups during the treatment period.Results The total effective rate in the observation group was higher than that in the control group(P＜0.05).Repeated measures analysis of vari-ance showed that there were interaction effects in TCM syndrome score,left ventricular ejection fraction(LVEF),cardiac index(CI),N-terminal pro-brain natriuretic peptide(NT-proBNP)and serum levels of IL-23,IL-17,vascular endothelial growth factor B(VEGF-B),von Willebrand factor(vWF),growth differentia-tion factor-15(GDF-15)of the two groups during treatment(F=13.455,10.336,7.513,17.011,23.468,25.178,14.556,13.182,18.712;P＜0.001),so further separate effect analysis was performed.Comparisons of serum levels of IL-23,IL-17,GDF-15,vWF,as well as TCM syndrome scores and NT-proBNP levels between the two groups at different time points showed that after 6 months of treatment＜after 3 months of treat-ment＜before treatment,and the difference was statistically significant in any pairwise comparison(P＜0.05).Comparisons of serum VEGF-B levels,LVEF,CI between the two groups at different time points showed that after 6 months of treatment＞after 3 months of treatment＞before treatment,and the differ-ence was statistically significant in any pairwise comparison(P＜0.05).The results of multivariate analysis of variance showed that the levels of serum IL-23,IL-17,vWF,GDF-15,NT-proBNP levels and TCM syndrome scores in the observation group were lower than those in the control group after 3 months and 6 months of treatment,and the level of serum VEGF-B,LVEF and CI were higher than those in the control group,with statistical significance(P＜0.05).There were no statistically significant differences in adverse reactions and MACE occurrence between the two groups during treatment(P＞0.05).Conclusion The combined applica-tion of Xinhuosu and Suxiao Jiuxin Pill in the treatment of AMI patients after PCI helps to downregulate the levels of serum IL-23 and IL-17,thereby improving the therapeutic effect.
万方数据
维普
